Active Recombinant Human FGF7 Protein

• Cat.No.: FGF7-90H
• Product Overview: Recombinant Human FGF7 Protein without tag was expressed in E. coli.

Specification

• Description: Fibroblast growth factor 7 (FGF-7), also known as keratinocyte growth factor (KGF), is a potent mitogen that regulates epithelial cell migration and differentiation. FGF-7 is produced by mesenchymal cells and binds in high affinity to a splice variant of FGF receptor 2 (FGFR2-IIIb). The mitogenic activity of FGF-7 acts predominantly on keratinocytes, but not on fibroblast or endothelial cells. FGF-7 expression is upregulated after acute and chronic injury, suggesting that FGF-7 functions during the healing of injured epithelial cells. FGF-7 also induces the formation of the apical ectodermal ridge during limb development.
• Source: E. coli
• Species: Human
• Bio-activity: 4MBr-5 cell proliferation, ≤60 ng/mL; ≥1.7 x 10^4 units/mg
• Molecular Mass: Monomer, 19 kDa (164 aa)
• AA Sequence: MCNDMTPEQMATNVNCSSPERHTRS YDYMEGGDIRVRRLFCRTQWYLRID KRGKVKGTQEMKNNYNIMEIRTVAV GIVAIKGVESEFYLAMNKEGKLYAK KECNEDCNFKELILENHYNTYASAK WTHNGGEMFVALNQKGIPVRGKKTK KEQKTAHFLPMAIT
• Endotoxin: ≤1 EUs/μg, Kinetic LAL
• Purity: ≥90%, Reducing and Non-Reducing SDS PAGE
• Stability: 12 months from date of receipt when stored at -20 to -80 centigrade as supplied.
  1 month when stored at 4 centigrade after reconstituting as directed.
  3 months when stored at -20 to -80 centigrade after reconstituting as directed.
• Storage: Storage Prior to Reconstitution: -20 centigrade
• Storage Buffer: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 100 mM sodium chloride, pH 7.5
• Reconstitution: Sterile water at 0.1 mg/mL
• Shipping: Room temperature
• Instructions: Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80 centigrade and avoid repeat freeze thaws.

Gene Information

• Gene Name: FGF7 fibroblast growth factor 7 [ Homo sapiens (human) ]
• Official Symbol: FGF7
• Synonyms: FGF7; fibroblast growth factor 7; fibroblast growth factor 7 (keratinocyte growth factor); keratinocyte growth factor; KGF; FGF-7; heparin-binding growth factor 7; HBGF-7
• Gene ID: 2252
• mRNA Refseq: NM_002009
• Protein Refseq: NP_002000
• MIM: 148180
• UniProt ID: P21781

Reviews

03/21/2022

I highly recommend the FGF7 Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

05/01/2021

The FGF7 Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.

10/01/2017

What truly distinguishes the FGF7 Protein is the unparalleled technical support provided by the manufacturer.

Q&As

How does FGF7 aid in tissue repair?

FGF7 stimulates the proliferation and migration of epithelial cells, which are crucial for repairing damaged tissues.

Are there any side effects associated with FGF7 treatment?

Side effects are generally mild, such as local irritation at the site of application, but comprehensive studies are ongoing.

Can FGF7 be used in regenerative medicine?

Yes, FGF7 is being explored for its potential in regenerating tissues and promoting healing in various medical fields.

How is FGF7 administered in clinical settings?

FGF7 can be administered topically or via injection, depending on the specific condition being treated.

Is FGF7 used in dermatology?

Yes, FGF7 has been investigated for its potential in treating skin disorders, including conditions like psoriasis and atopic dermatitis.