Active Recombinant Human GDF1 Protein

• Cat.No.: GDF1-045H
• Product Overview: The mature recombinant human GDF-1 protein (254-372aa) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 254-372 a.a.
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations.
• Bio-activity: Measured by its ability to induce Smad2 phosphorylation in P19 mouse embryonal carcinoma cells. 50 ng/mL of Recombinant Human GDF-1 can effectively induce Smad2 phosphorylation.
• Molecular Mass: 12.6 kDa
• Product-Related Proteins: 254-372
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF1 growth differentiation factor 1 [ Homo sapiens (human) ]
• Official Symbol: GDF1
• Synonyms: GDF1; growth differentiation factor 1; RAI; DORV; LAG1; UOG1; CERS1; CHTD6; DTGA3; LASS1; embryonic growth/differentiation factor 1; Ceramide synthase 1; LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1
• Gene ID: 2657
• mRNA Refseq: NM_001492
• Protein Refseq: NP_001483
• MIM: 602880
• UniProt ID: P27539