Species : |
Human |
Source : |
E.coli |
Protein Length : |
254-372 a.a. |
Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. |
Bio-activity : |
Measured by its ability to induce Smad2 phosphorylation in P19 mouse embryonal carcinoma cells. 50 ng/mL of Recombinant Human GDF-1 can effectively induce Smad2 phosphorylation. |
Molecular Mass : |
12.6 kDa |
Product-Related Proteins : |
254-372 |
Endotoxin : |
< 0.1 EU/μg of the protein as determined by the LAL method |
Purity : |
> 95 % as determined by SDS-PAGE |
Storage : |
At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : |
PBS |