Active Recombinant Human HBEGF Protein
Cat.No. : | HBEGF-269H |
Product Overview : | Recombinant Human HBEGF Protein without tag was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | Proheparin-binding EGF-like growth factor (HB-EGF), also known as DTR, DTS and HEGFL, is a member of the EGF family of mitogens. It is expressed in macrophages, monocytes, endothelial cells and muscle cells. HB-EGF signals through the EGF receptor to stimulate the proliferation of smooth muscle cells, epithelial cells and keratinocytes. Compared to EGF, HB-EGF binds the EGF receptor with higher affinity and is thus more mitogenic, probably due to its ability to bind to heparin and heparin sulfate proteoglycans. HB-EGF has been reported to act as a diphtheria toxin receptor, mediating endocytosis of the bound toxin. |
Source : | CHO |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 0.5 ng/mL, measured in a cell proliferation assay using 3T3 cells. |
Molecular Mass : | 12-14 kDa, observed by reducing SDS-PAGE. |
AA Sequence : | DLQEADLDLLRVTLSSKPQALATPN KEEHGKRKKKGKGLGKKRDPCLRKY KDFCIHGECKYVKELRAPSCICHPG YHGERCHGLSL |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE and HPLC. |
Storage : | Lyophilized recombinant Human HB-EGF remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human HB-EGF should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
Gene Name : | HBEGF heparin-binding EGF-like growth factor [ Homo sapiens ] |
Official Symbol : | HBEGF |
Synonyms : | HBEGF; heparin-binding EGF-like growth factor; diphtheria toxin receptor (heparin binding epidermal growth factor like growth factor), DTR, DTS, HEGFL; proheparin-binding EGF-like growth factor; Diphtheria toxin receptor (heparin binding EGF like growth factor); heparin binding epidermal growth factor; heparin-binding epidermal growth factor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DTR; DTS; DTSF; HEGFL; |
Gene ID : | 1839 |
mRNA Refseq : | NM_001945 |
Protein Refseq : | NP_001936 |
MIM : | 126150 |
UniProt ID : | Q99075 |
Products Types
◆ Recombinant Protein | ||
HBEGF-957H | Recombinant Human HBEGF Protein, His-tagged | +Inquiry |
HBEGF-056H | Active Recombinant Human HBEGF Protein | +Inquiry |
HBEGF-4076M | Recombinant Mouse HBEGF Protein, His (Fc)-Avi-tagged | +Inquiry |
HBEGF-2526H | Recombinant Human HBEGF Protein (63-148 aa), His-tagged | +Inquiry |
HBEGF-2455R | Recombinant Rat HBEGF Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HBEGF-551HCL | Recombinant Human HBEGF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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