Active Recombinant Human ICOS, HIgG1 Fc-tagged, mutant

Cat.No. : ICOS-1532H
Product Overview : The extracellular domain of human CD278 [ICOS] (NP_036224.1) (Glu21-Leu139) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell
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Description : The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimersand plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit human T cell proliferation induced by rhB7-H2/Fc Chimera in the presence of anti-CD3.
Molecular Mass : 40 KDa (monomer)
AA Sequence : Glu21-Leu139
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : ICOS inducible T-cell co-stimulator [ Homo sapiens ]
Official Symbol : ICOS
Synonyms : ICOS; inducible T-cell co-stimulator; inducible T-cell costimulator; activation inducible lymphocyte immunomediatory molecule; AILIM; CD278; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule; CVID1; MGC39850;
Gene ID : 29851
mRNA Refseq : NM_012092
Protein Refseq : NP_036224
MIM : 604558
UniProt ID : Q9Y6W8
Chromosome Location : 2q33
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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