Active Recombinant Human IL16 protein IL16-126H

Active Recombinant Human IL16 protein


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Active Recombinant Human IL16 protein

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Cat.No. : IL16-126H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human IL16 was expressed in E. coli.
Description : Interleukin 16 (IL16) is a pleiotrophic cytokine derived from CD8+ T-cells that stimulates chemotaxis in CD4+ lymphocytes, monocytes, and eosinophils. It primes CD4+ T-cells for IL2 and IL15 responsiveness, induces T-lymphocyte Interleukin 2 (IL2) receptor expression, and inhibits HIV replication. The signalling process of IL16 is mediated by CD4, and undergoes proteolysis to yield two functional proteins. IL16 isoform 1 has the possible function of acting as a scaffolding protein to anchor ion channels in the membrane, while isoform 3 is involved in cell cycle progression in T-cells and transcriptional regulation of SKP2. IL16 mRNA expression levels have been found in various tissues such as spleen, bone marrow, thymus, and lymph nodes.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : The ED50 is 7.5-37.5 ng/mL as determined by its ability to chemoattract human CD4+ T lymphocytes (at a concentration range of 1.0-100.0 ng/mL).
Molecular Mass : 13.5 kDa
Endotoxin : <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity : >95%
Applications : Cell Assay
Storage : The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade - 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Reconstitution : Reconstitute in sterile PBS at 5 μg/Ml
Figure :

Gene Name : IL16 interleukin 16 [ Homo sapiens ]
Official Symbol : IL16
Synonyms : IL16; interleukin 16; interleukin 16 (lymphocyte chemoattractant factor); pro-interleukin-16; FLJ16806; FLJ42735; HsT19289; IL 16; LCF; lymphocyte chemoattractant factor; prIL 16; prointerleukin 16; neuronal interleukin 16; NIL16; PRIL16; prIL-16; FLJ44234;
Gene ID : 3603
mRNA Refseq : NM_001172128
Protein Refseq : NP_001165599
MIM : 603035
UniProt ID : Q14005
Chromosome Location : 15q26.3
Function : cytokine activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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