Active Recombinant Human Il1B, HIgG1 Fc-tagged, mutant

• Cat.No.: Il1B-464H
• Product Overview: The extracellular domain of human IL-1b (NP_000567.1)(Ala117-Ser269) is fused to the N-terminus of the Fc region of mutant human IgG1was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 117-269 a.a.
• Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced byactivated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety ofcellular activities, including cell proliferation, differentiation, and apoptosis. The induction ofcyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute toinflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine genecluster on chromosome 2.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: cytokine activity; interleukin-1 receptor binding; protein binding
• Molecular Mass: 43KDa (monomer)
• AA Sequence: Ala117-Ser269
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL1B interleukin 1, beta [ Homo sapiens ]
• Official Symbol: IL1B
• Synonyms: IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA
• Gene ID: 3553
• mRNA Refseq: NM_000576
• Protein Refseq: NP_000567
• MIM: 147720
• UniProt ID: P01584
• Chromosome Location: 2q14
• Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem
• Function: cytokine activity; cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding