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Active Recombinant Human IL6, MIgG2a Fc-tagged, mutant

Cat.No. : IL6-314H
Product Overview : The extracellular domain of mouse IL-6 (NP_112445.1)(Met1-Thr211) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a was expressed in CHO cell.
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  • Gene Information
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Description : This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, theencoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmunediseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it issecreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor,alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states,including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
Source : CHO cells
Species : Mouse
Tag : MIgG2a Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by the dose-dependent stimulation of the proliferation of IL-6 dependent mouse 7TD1 cells
Molecular Mass : 51KDa
AA Sequence : Met1-Thr211
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : ≥98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : Il6 interleukin 6 [ Mus musculus ]
Official Symbol : IL6
Synonyms : IL6; interleukin 6; interleukin-6; interleukin HP-1; B-cell hybridoma growth factor; Il-6;
Gene ID : 16193
mRNA Refseq : NM_031168
Protein Refseq : NP_112445
Pathway : Adipogenesis, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem;
Function : cytokine activity; cytokine activity; growth factor activity; interleukin-6 receptor binding; interleukin-6 receptor binding; protein binding; receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the dosage and usage of Il6? 07/15/2022

The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.

What are the pharmacokinetic properties of Il6? 06/16/2022

The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.

Does Il6 have advantages in the treatment of multiple myeloma? 04/22/2022

Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.

Does Il6 have specific therapeutic effects for certain diseases? 05/27/2020

Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.

In which diseases is Il6 widely used? 11/20/2019

This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.

What is the effect of Il6 on immune cells? 05/21/2019

The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.

Customer Reviews (3)

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Reviews
03/05/2022

    Accurate localization and function within the cell.

    01/31/2021

      The binding affinity and affinity constant with the target are high.

      03/12/2020

        Can form a stable micellar structure.

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