Active Recombinant Human Interleukin 16

• Cat.No.: IL16-534H
• Product Overview: Recombinant human IL16 was expressed in E. coli and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: IL16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL16 exists predominantly as a noncovalently linked multimer, but that some IL16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL16 also induces expression of IL2 receptor (IL2R) and MHC class II molecules on CD4 + T cells. Human and Mouse IL16 show significant cross-species reactivity.
• Form: Supplied as a lyophilized powder.
• Purity: >98% pure by SDS PAGE and HPLC
• Sequence: Region of IL16 protein corresponding to amino acids SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S.
• Molecular Mass: 13.5 kDa
• Applications: Numerous applications are possible with this product and should be tested by the end user under their own laboratory conditions
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Bioactivity: Determined by its ability ot chemoattract human CD4+ T-lymphoytes using a concentration range of 50.0-100.0 ng/ml.
• Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: IL16 interleukin 16 [ Homo sapiens ]
• Official Symbol: IL16
• Synonyms: IL16; FLJ16806; FLJ42735; FLJ44234; LCF; prIL-16; Interleukin-16; Lymphocyte Chemoattractant Factor; prIL-16; IL-16; HsT19289; interleukin-16 precursor; interleukin 16 (lymphocyte chemoattractant factor)
• Gene ID: 3603
• mRNA Refseq: NM_004513
• Protein Refseq: NP_004504
• MIM: 603035
• UniProt ID: Q14005
• Chromosome Location: 15q26.3
• Pathway: immune response; induction of positive chemitaxis; leukocyte chemitaxis
• Function: cytokine activity; protein binding