Active Recombinant Human Interleukin 2, His-tagged
Cat.No. : | IL2-8861H |
Product Overview : | Recombinant Human Interleukin 2 was produced in the endosperm tissue of barley grain (Hordeum vulgare). |
- Specification
- Gene Information
- Related Products
Description : | Interleukin 2 (IL-2) is a potent immunoregulatory growth factor produced by T-cells following stimulation by mitogens or allogens. IL-2 promotes growth and differentiation of various cells of the immune system, such as activated T-cells and B-cells, NK cells, lymphokine activated killer cells, monocytes and macrophages. It is essential for proper immune response, it may also be an important factor in the natural suppression of autoimmunity. IL-2 may be of use as an anti-tumor agent in cancer therapy. |
Source : | Hordeum vulgare |
Species : | Human |
Predicted N Terminal : | His |
Form : | Sterile filtered through a 0.2 μm filter. Lyophilized from PBS, pH 7.2. |
Bio-activity : | Bioactivity of recombinant human IL-2 is assayed by measuring its dose dependent effect on proliferation of CTLL-2 cells. The ED50 for this effect is typically< 0.25 ng/ml, corresponding to a specific activity>4 x10e6 U/mg. |
Molecular Mass : | Recombinant human IL-2 contains 133 amino acids and a 16 a.a. histidine-based tag for a total length of 149 a.a. and has a predicted molecular mass of 17.5 kDa. The recombinant protein migrates with an apparent molecular mass of 22 kDa in SDS-PAGE. |
Endotoxin : | Endotoxin level is less than 0.05EU/μg as measured by turbidimetric kinetic assay. |
Purity : | >95% by SDS-PAGE gel analysis. |
Storage : | The lyophilized protein is stable at room temperature for few weeks. Reconstituted protein should be used immediately or stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). |
Gene Name : | IL2 interleukin 2 [ Homo sapiens ] |
Official Symbol : | IL2 |
Synonyms : | IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; involved in regulation of T-cell clonal expansion; IL-2; lymphokine; |
Gene ID : | 3558 |
mRNA Refseq : | NM_000586 |
Protein Refseq : | NP_000577 |
MIM : | 147680 |
UniProt ID : | P60568 |
Chromosome Location : | 4q26-q27 |
Pathway : | Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; |
Function : | carbohydrate binding; cytokine activity; glycosphingolipid binding; growth factor activity; interleukin-2 receptor binding; interleukin-2 receptor binding; kappa-type opioid receptor binding; kinase activator activity; |
Products Types
◆ Recombinant Protein | ||
IL2-0016H | Recombinant Human IL2 Protein | +Inquiry |
IL2-14H | Recombinant Human IL2 Protein | +Inquiry |
IL2-155H | Active Recombinant Human IL2 Protein | +Inquiry |
IL2-1026H | Recombinant Human IL2 Protein, His-tagged | +Inquiry |
Il2-105M | Active Recombinant Mouse Il2 Protein | +Inquiry |
◆ Lysates | ||
IL2-5234HCL | Recombinant Human IL2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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