Active Recombinant Human LGALS2 Protein (Thr2-Glu132), N-His tagged, Animal-free, Carrier-free

• Cat.No.: LGALS2-190H
• Product Overview: Recombinant Human LGALS2 Protein (Thr2-Glu132) with N-His tag was expressed in E. coli and Animal-free as well as Carrier-free.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Thr2-Glu132
• Description: Galectin-2 (Gal-2) is a lectin family member and structurally closely related to galectin-1. It contains one carbohydrate recognition domain (CRD), responsible for β-galactoside binding, and is biologically active as homodimers. Galectin-2 serves as a proapoptotic effector for activated T cells through caspase-3 signaling. Moreover, galectin-2 has emerged as a crucial factor in driving the macrophage to CD40-positive M1 polarization, leading to arteriogenesis attenuation and collateral arteries remodeling.
• Form: Lyophilized
• Bio-activity: Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is < 20 μg/mL.
• Molecular Mass: The protein has a calculated MW of 15.5 kDa.
  The protein migrates as 15 kDa under reducing condition (SDS-PAGE analysis).
• Endotoxin: < 0.1 EU/μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE analysis.
• Storage: This product is stable after storage at:
  -20 centigrade for 12 months in lyophilized state from date of receipt.
  -20 or -80 centigrade for 1 month under sterile conditions after reconstitution.
  Avoid repeated freeze/thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage.
• Publications:
  Toward a new and noninvasive diagnostic method of papillary thyroid cancer by using peptide vectorized contrast agents targeted to galectin-1 (2017)

Gene Information

• Gene Name: LGALS2 lectin, galactoside-binding, soluble, 2 [ Homo sapiens (human) ]
• Official Symbol: LGALS2
• Synonyms: LGALS2; lectin, galactoside-binding, soluble, 2; galectin-2; galectin 2; HL14; gal-2; S-Lac lectin 2; lactose-binding lectin 2; beta-galactoside-binding lectin L-14-II; MGC75071
• Gene ID: 3957
• mRNA Refseq: NM_006498
• Protein Refseq: NP_006489
• MIM: 150571
• UniProt ID: P05162