Active Recombinant Human OSM, Fc-tagged, Biotinylated

Cat.No. : OSM-657H
Product Overview : The recombinant human OSM-Fc is expressed as a 433-amino acid active form consisting of Ala26 - Arg220 region of (UniProt accession #P13725) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.
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Source : Human cells
Species : Human
Tag : Fc
Form : Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
Bio-activity : Stimulates TF-1 human erythroleukemic cell proliferation assay with an ED50 typically 0.2 - 0.5 ng/ml. Supports the maintenance of embryonic stem (ES) cell pluripotency and germline competency.
Molecular Mass : Calculated molecular mass (kDa): 48.7; Estimated by SDS-PAGE under reducing condition (kDa): ~55
AA Sequence : AAIGSCSKEYRVLLGQLQKQTDLMQ DTSRLLDPYIRIQGLDVPKLREHCR ERPGAFPSEETLRGLGRRGFLQTLN ATLGCVLHRLADLEQRLPKAQDLER SGLNIEDLEKLQMARPNILGLRNNI YCMAQLLDNSDTAEPTKAGRGASQ PPTPTPASDAFQRKLEGCRFLHGYH RFMHSVGRVFSKWGESPNRSRSTTE NLYFQGSTGTHTCPPCPAPELLGG PSVFLFPPKPKDTLMISRTPEVTCV VVDVSHEDPEVKFNWYVDGVEVHNA KTKPREEQYNSTYRVVSVLTVLHQ DWLNGKEYKCKVSNKALPAPIEKTI SKAKGQPREPQVYTLPPSREEMTKN QVSLTCLVKGFYPSDIAVEWESNG QPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNH YTQKSLSLSPGK
Endotoxin : <0.1 eu per 1 μg of purified recombinant protein determined by the lal>
Purity : >95% judged by SDS-PAGE under reducing condition
Storage : The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
Gene Name : OSM oncostatin M [ Homo sapiens ]
Official Symbol : OSM
Synonyms : OSM; oncostatin M; oncostatin-M; MGC20461;
Gene ID : 5008
mRNA Refseq : NM_020530
Protein Refseq : NP_065391
MIM : 165095
UniProt ID : P13725
Chromosome Location : 22q12.2
Pathway : Adipogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity; growth factor activity; oncostatin-M receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the impact of OSM on cancer development and progression, particularly in terms of tumor microenvironment modulation? 03/25/2022

OSM can influence cancer progression by altering the tumor microenvironment and affecting tumor cell behavior.

How does OSM (Oncostatin M) regulate inflammatory and immune responses in the body? 01/30/2021

OSM plays a key role in regulating inflammatory and immune responses, modulating cytokine production and immune cell activity.

How does OSM contribute to wound healing and tissue regeneration processes? 06/08/2020

OSM aids in wound healing and tissue regeneration, promoting cell growth and repair mechanisms.

What role does OSM play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 04/27/2020

OSM is implicated in autoimmune diseases, contributing to inflammation and joint damage in conditions like rheumatoid arthritis.

How does OSM influence liver fibrosis and hepatic diseases? 03/17/2020

OSM is involved in liver fibrosis, impacting the development and progression of hepatic diseases.

What are the mechanisms by which OSM modulates cellular growth, differentiation, and apoptosis? 06/22/2018

OSM regulates cellular processes like growth, differentiation, and apoptosis, affecting various tissue functions.

How do alterations in OSM expression or signaling affect cardiovascular health and disease? 02/20/2018

Changes in OSM signaling can impact cardiovascular health, influencing disease development and progression.

Customer Reviews (3)

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Reviews
11/25/2020

    Outstanding protein-protein interaction studies, vital for our projects.

    03/02/2020

      High-quality protein characterization, fundamental for our experiments.

      02/27/2019

        Expertise in peptide synthesis, accelerates our peptide-based research.

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