Active Recombinant Human PDCD1, HIgG1 Fc-tagged, mutant

Cat.No. : PDCD1-034H
Product Overview : The extracellular domain of human CD279 [PD-1] (NP_005009.2) (Leu25-Gln167) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell.
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Description : This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases
Source : CHO cells
Species : Human
Tag : HIgG1 Fc-tagged, mutant
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : 46 KDa (monomer)
AA Sequence : Leu25-Gln167
Endotoxin : <0.06 eu/μg as determined by lal test.>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Protein length : Leu25-Gln167
Gene Name : PDCD1 programmed cell death 1 [ Homo sapiens ]
Official Symbol : PDCD1
Synonyms : PDCD1; programmed cell death 1; programmed cell death protein 1; CD279; PD1; protein PD-1; PD-1; SLEB2; hPD-1; hPD-l;
Gene ID : 5133
mRNA Refseq : NM_005018
Protein Refseq : NP_005009
MIM : 600244
UniProt ID : Q15116
Chromosome Location : 2q37.3
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; T cell receptor signaling pathway, organism-specific biosystem;
Function : protein binding; protein tyrosine phosphatase activity; signal transducer activity;

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
06/06/2021

    Timely antibody validation, a valuable asset for our laboratory.

    02/12/2021

      Precise protein quantification, fundamental for maintaining data accuracy.

      06/20/2019

        Dependable peptide synthesis, accelerates our peptide-based projects effectively.

        Q&As (14)

        Ask a question
        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 07/31/2022

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What are the mechanisms by which PDCD1 modulates the immune response to viral infections? 11/09/2021

        PDCD1 modulates responses to viral infections, affecting T cell function and viral clearance.

        What role does PDCD1 play in the development of immune tolerance? 10/15/2021

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 05/23/2021

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 08/13/2020

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 influence the balance between immune activation and autoimmunity? 08/05/2020

        PDCD1 maintains a balance between immune response and autoimmunity, preventing self-reactivity.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 12/05/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        How does PDCD1 contribute to the exhaustion of T cells in chronic infections and cancer? 11/21/2019

        PDCD1 contributes to T cell exhaustion in chronic diseases and cancers, reducing immune efficacy.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 04/24/2019

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        What is the impact of PDCD1 on the effectiveness of immunotherapy in treating cancers? 01/19/2019

        PDCD1's role in immunotherapy is pivotal, as blocking PD-1 enhances anti-tumor responses.

        What role does PDCD1 play in the development of immune tolerance? 12/08/2018

        PDCD1 helps develop immune tolerance, preventing overactive immune responses.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 06/24/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

        How does PDCD1 (PD-1) regulate immune checkpoint pathways in T cells? 06/24/2018

        PDCD1 regulates T cell activity by inhibiting immune responses, crucial in immune checkpoints.

        How do alterations in PDCD1 expression or signaling affect autoimmune disease progression? 02/06/2018

        Changes in PDCD1 signaling impact autoimmune disease progression, influencing immune system activity.

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