Active Recombinant Human PIP5K1C protein, GST-tagged
Cat.No. : | PIP5K1C-172H |
Product Overview : | Recombinant Human PIP5K1C fused with an N-terminal GST tag was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | PIP5K1C or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with β-catenin and increases β-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance β-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitating RhoA GTPase and integrin activation by chemoattractants. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 8150 nmol/min/mg |
Molecular Mass : | 120 kDa |
Purity : | >70% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from the date of shipment |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05μg/μl |
Gene Name : | PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [ Homo sapiens ] |
Official Symbol : | PIP5K1C |
Synonyms : | PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; KIAA0589; LCCS3; PIP5Kgamma; PIP5K1-gamma; type I PIP kinase; diphosphoinositide kinase; ptdIns(4)P-5-kinase 1 gamma; Human homolog of mouse phosphatidylinositol-4-phosphate 5-kinase I-gamma; PIPKIg_v4; PIP5K-GAMMA; |
Gene ID : | 23396 |
mRNA Refseq : | NM_012398 |
Protein Refseq : | NP_036530 |
MIM : | 606102 |
UniProt ID : | O60331 |
Chromosome Location : | 19p13.3 |
Pathway : | 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Arf6 trafficking events, organism-specific biosystem; Axon guidance, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; |
Function : | 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; nucleotide binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
PIP5K1C-6757M | Recombinant Mouse PIP5K1C Protein, His (Fc)-Avi-tagged | +Inquiry |
Pip5k1c-4875M | Recombinant Mouse Pip5k1c Protein, Myc/DDK-tagged | +Inquiry |
PIP5K1C-3794H | Recombinant Human PIP5K1C protein, His-tagged | +Inquiry |
PIP5K1C-12830M | Recombinant Mouse PIP5K1C Protein | +Inquiry |
PIP5K1C-1462H | Active Recombinant Human PIP5K1C, GST-tagged | +Inquiry |
◆ Lysates | ||
PIP5K1C-3172HCL | Recombinant Human PIP5K1C 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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