Active Recombinant Mouse Flt3l

• Cat.No.: Flt3l-03M
• Product Overview: Flt3-Ligand Mouse Recombinant produced in E.Coli is non-glycosylated, polypeptide chain containing 163 amino acids and having a molecular mass of 18587 Dalton. Flt3-Ligand is purified by proprietary chromatographic techniques.

Specification

• Description: FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation.
• Source: E.Coli
• Species: Mouse
• Form: Sterile Filtered White lyophilized (freeze-dried) powder. The FLT3L Mouse protein was lyophilized without any additives.
• Bio-activity: The ED50, calculated by the dose-dependent proliferation of mouse AML5 cells is 1.3-2.0ng/ml.
• Molecular Mass: 18587 Dalton
• AA Sequence: MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCKALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP LPECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQPDSS TLLPPRSPIA LEATELPEPR PRQ.
• Purity: Greater than 98.0% as determined by SDS-PAGE.
• Stability: Lyophilized Flt3-Ligand although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Flt-3 Ligand should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Reconstitution: It is recommended to reconstitute the lyophilized Flt3-Ligand in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Gene Information

• Gene Name: Flt3l FMS-like tyrosine kinase 3 ligand [ Mus musculus (house mouse) ]
• Official Symbol: Flt3l
• Synonyms: Flt3l; FMS-like tyrosine kinase 3 ligand; Ly72L; Flt3lg; Flt3l; Fms-related tyrosine kinase 3 ligand; FLK2; STK1; CD135; Stem Cell Tyrosine Kinase 1; FLT3LG; Flt3.
• Gene ID: 14256
• mRNA Refseq: NM_013520
• Protein Refseq: NP_038548
• UniProt ID: P49772
• Chromosome Location: 7 B2-C; 7 29.14 cM
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
• Function: cytokine activity; protein homodimerization activity; receptor tyrosine kinase binding