Active Recombinant Mouse Il17f Protein
|Product Overview :||Purified recombinant protein of Mouse interleukin 17F (Il17f) (Arg29-Ala161) without tag was expressed in E.coli.|
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|Description :||Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.|
|Source :||E. coli|
|Bio-activity :||The ED50 is 300 to 600 ng/ml, corresponding to a specific activity of 0.16 - 0.33 x 10^4 units/mg, determined by a dose dependent stimulation of fetal mouse skin fibroblasts production of CXCL1.|
|Molecular Mass :||15 kDa|
|Endotoxin :||Less than 0.01 ng per µg protein as determined by the LAL method|
|Purity :||>98%, as determined by Coomassie stained SDS-PAGE.|
|Stability :||Unopened vial can be stored between 2 centigrade and 8 centigrade for up to 2 weeks, at -20 centigrade for up to 6 months, or at -70 centigrade or below until the expiration date. Aliquots can be stored between 2 centigrade and 8 centigrade for up to one week and stored at -20 centigrade or colder for up to 3 months. Avoid repeated freeze/thaw cycles.|
|Storage :||Store at -80 centigrade.|
|Concentration :||Protein formulated and vialed at >50 ug/mL in specified buffer|
|Storage Buffer :||10 mM NaH2PO4, 0.15 M NaCl, pH7.2|
|Gene Name :||Il17f interleukin 17F [ Mus musculus (house mouse) ]|
|Official Symbol :||Il17f|
|Synonyms :||Il17f; interleukin 17F; C87042; IL-17F; interleukin-17F|
|Gene ID :||257630|
|mRNA Refseq :||NM_145856|
|Protein Refseq :||NP_665855|
|UniProt ID :||Q7TNI7|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Tumor xenografts, immune cell infiltration analysis, and therapeutic antibody testing assess IL17F's role in cancer.
Neutrophil chemotaxis assays, in vivo neutrophil tracking, and immune cell activation analysis explore IL17F's impact on neutrophil functions.
Genetic knockout models, functional assays, and gene expression analyses distinguish IL17F's unique roles.
Microbiota composition analysis, germ-free models, and immune cell profiling investigate IL17F-microbiota interactions.
Animal disease models, patient samples, and immunological assays elucidate IL17F's contribution to autoimmune diseases.
Co-immunoprecipitation, fluorescence resonance energy transfer (FRET), and pathway-specific assays elucidate IL17F's heterodimerization and signaling.
Comparative cytokine profiling, inflammatory assays, and pathway analysis dissect IL17F's interplay with other immune mediators.
Allergen challenges, inflammatory disease models, and gene expression profiling probe IL17F's involvement in chronic conditions.
Epithelial barrier permeability assays, tissue section analysis, and cell culture models study IL17F's effects on barrier integrity.
Wound healing assays, tissue regeneration models, and histological analyses examine IL17F's effects on tissue repair.
Customer Reviews (3)Write a review
High specificity. -
Good for receptor studies. -
Potent in anti-bacterial assays. -
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