Active Recombinant Mouse Interleukin 23, Alpha Subunit P19
Cat.No. : | Il23a-651M |
Product Overview : | RecombinantMouse Il23a protein was expressed in Spodopterafrugiperda. Met23-Ser335 (N-terminus), Leu20-Ala196 (C-terminus). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Il23a-651M |
Description : | Il23a isa heterodimeric cytokine composed of two disulfide-linked subunits, a p19subunit that is unique to Il23a, and a p40 subunit that is shared with IL-12.The Il23a homology to the p35 subunit of IL-12, as well as to other singlechain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to theextracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNAencodes a 196 amino acid residue (aa) precursor protein with a putative 19 aasignal peptide and 177 aa mature protein. Human and mouse Il23a share 70% aasequence identity. Although p19 is expressed by activated macrophages,dendritic cells, T cells, and endothelial cells, only activated macrophagesand dendritic cells express p40 concurrently to produce Il23a. |
Source : | Spodoptera frugiperda, Sf 21(baculovirus)-derived. |
Form : | Lyophilizedfrom a 0.2 um filtered solution in PBS with BSA as a carrier protein. |
N-terminalSequence : | Met23 |
MolecularWeight : | 57 kDa |
Activity : | Measuredby its ability to induce IL-17 secretion by mouse splenocytes. The ED 50 for thiseffect is typically 0.05-0.25 ng/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 66 kDa,reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 10μg/mL in sterile PBS containing at least 0.1% human or bovine serumalbumin. |
Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution. |
Gene Name : | Il23ainterleukin 23, alpha subunit p19 [ Mus musculus ] |
Official Symbol : | Il23a |
Synonyms : | Il23a; interleukin23, alpha subunit p19; p19; IL-23; interleukin-23 subunit alpha;IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin-23 subunit p19 |
Gene ID : | 83430 |
mRNA Refseq : | NM_031252 |
Protein Refseq : | NP_112542 |
UniProt ID : | Q9EQ14 |
Chromosome Location : | 10 |
Pathway : | Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway; Pertussis; Rheumatoidarthritis; Tuberculosis |
Function : | cytokine activity;contributes_to interleukin-23 receptor binding; protein binding |
Products Types
◆ Recombinant Protein | ||
Il23A-23H | Recombinant Human Il23A&IL12B Protein, His-tagged | +Inquiry |
Il23a-2304M | Recombinant Mouse Il23a Protein, His-tagged | +Inquiry |
IL23A-451H | Recombinant Human IL23A Protein, Fc-tagged | +Inquiry |
Il23a-1927M | Recombinant Mouse Il23a Protein | +Inquiry |
Il23a-2305M | Recombinant Mouse Il23a Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL23A-5231HCL | Recombinant Human IL23A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket