Active Recombinant Mouse Interleukin 27, MIgG2a Fc-tagged

• Cat.No.: IL27-405M
• Product Overview: The mouse IL-27 complex composed of the Ebi3 subunitv (NP_056581.1)(aa 1-228) and the p28 subunit (AAI19403.1)(aa29-234) is fused through a polypeptide linker to the Fc portion of mouse IgG2a was expressed in CHO cell.

Specification

• Description: IL27 (interleukin 27) is a protein-coding gene. Diseases associated with IL27 include human t-cell leukemia virus type 1, and visceral leishmaniasis, and among its related super-pathways are Th1 Differentiation. GO annotations related to this gene include interleukin-27 receptor binding and receptor binding.
• Source: CHO cell
• Species: Mouse
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Bioactivity was measured in a cell proliferation assay of Con A activated mouse splenocytes.
• Molecular Mass: 76KDa
• AA Sequence: The mouse IL-27 complex composed of the Ebi3 subunitv (NP_056581.1)(aa 1-228) and the p28 subunit (AAI19403.1)(aa29-234) is fused through a polypeptide linker to the Fc portion of mouse IgG2a.
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: ≥98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il27 interleukin 27 [ Mus musculus ]
• Official Symbol: IL27
• Synonyms: IL27; interleukin 27; interleukin-27 subunit alpha; IL27-A; IL-27-A; interleukin 30; IL-27 p28 subunit; IL-27 subunit alpha; p28; Il30; IL-27; IL-27p28
• Gene ID: 246779
• mRNA Refseq: NM_145636
• Protein Refseq: NP_663611
• Function: cytokine activity; interleukin-27 receptor binding; protein binding; receptor binding

Reviews

03/30/2022

The purity is very high, no impurities.

08/05/2020

Biological activity is very strong and can be used in various biological experiments.

05/30/2019

Stability is very good, and it will not denaturate at high temperatures.

Q&As

Are there have current difficulties in the study of Il27?

The current challenges in the study of Il27 include potential side effects, preparation purity and other challenges.

Which scientific research fields are deeply studying Il27?

The potential application of Il27 in tumor immunotherapy and autoimmune diseases is being deeply studied in the scientific research field.

Is the production of Il27 related to genetic factors?

The production of Il27 is related to genetic factors, and the expression level and polymorphism of genes may affect its production and function.

Which role of Il27 in inflammatory diseases?

Studies have shown that Il27 may have an anti-inflammatory effect in inflammatory diseases, regulating the degree of inflammatory response.

What the potential applications of recombinant Il27 in cancer therapy?

Current studies have shown that Il27 has potential application value in enhancing anti-tumor immunity and alleviating tumor invasion and metastasis.

What is the effect of Il27 on immune response?

Il27 can enhance the activation and proliferation of specific immune cells and regulate the intensity and direction of immune response.