Active Recombinant Rat Il6 Protein
| Cat.No. : | Il6-176I |
| Product Overview : | Recombinant Rat Il6 Protein without tag was expressed in HEK 293. |
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| Description : | Interleukin-6 (IL-6) is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, Interleukin-6 (IL-6) has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. Interleukin-6 (IL-6) signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. |
| Source : | HEK 293 |
| Species : | Rat |
| Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : | ED50 < 3 pg/mL, measured by a cell proliferation assay using 7TD1 Cells. |
| Molecular Mass : | 21~26 kDa, observed by reducing SDS-PAGE. |
| AA Sequence : | FPTSQVRRGDFTEDTTHNRPVYTTS QVGGLITYVLREILEMRKELCNGNS DCMNSDDALSENNLKLPEIQRNDGC FQTGYNQEICLLKICSGLLEFRFYL EFVKNNLQDNKKDKARVIQSNTETL VHIFKQEIKDSYKIVLPTPTSNALL MEKLESQKEWLRTKTIQLILKALEE FLKVTMRSTRQT |
| Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
| Purity : | > 95% as analyzed by SDS-PAGE. |
| Storage : | Lyophilized recombinant Rat Interleukin-6(IL-6) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, it should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
| Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
| Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/mL. |
| Gene Name : | Il6 interleukin 6 [ Rattus norvegicus ] |
| Official Symbol : | Il6 |
| Synonyms : | IL6; interleukin 6; interleukin-6; IL-6; Interleukin 6 (interferon, beta 2); ILg6; Ifnb2; |
| Gene ID : | 24498 |
| mRNA Refseq : | NM_012589 |
| Protein Refseq : | NP_036721 |
| UniProt ID : | P20607 |
Products Types
| ◆ Lysates | ||
| IL6-5224HCL | Recombinant Human IL6 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewAccurate localization and function within the cell.
The binding affinity and affinity constant with the target are high.
Can form a stable micellar structure.
Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
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