Bovine Transforming Growth Factor beta-1 Reference standard
Cat.No. : | TGFB1-96B |
Product Overview : | As a biological reference standard for transforming growth factor-beta1 (TGF-β1). |
Availability | February 18, 2025 |
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Species : | Bovine |
Enzyme Unit : | The assigned potency is 1,500 arbitrary units per ampoule. |
Usage : | No attempt should be made to weigh out any portion of the freeze-dried material prior to reconstitution. Dissolve the total contents of the ampoule with 0.5ml of sterile distilled water. Rinse the ampoule with about 0.4ml of sterile distilled water and make up the total volume to 1.0ml with sterile distilled water. This solution should now contain TGF beta 1 at a concentration of 1,500 Units/ml. Use carrier protein where extensive dilution is required. |
Notes : | This preparation is not for administration to humans. The preparation contains material of human origin, and either the final product or the source materials, from which it is derived, have been tested and found negative for HBsAg, anti-HIV and HCV RNA. The bovine TGF- β1 was sourced from a country where bovine spongiform encephalopathy (BSE) has not been found. As with all materials of biological origin, this preparation should be regarded as potentially hazardous to health. It should be used and discarded according to your own laboratorys safety procedures. Such safety procedures should include the wearing of protective gloves and avoiding the generation of aerosols. Care should be exercised in opening ampoules or vials, to avoid cuts. |
Stability : | Reference materials are held at Creative Biomart within assured, temperature- controlled storage facilities and they should be stored on receipt as indicated on the label. Accelerated degradation studies have indicated that this material is suitably stable, when stored at -20°C or below, for the assigned values to remain valid until the material is withdrawn or replaced. These studies have also shown that the material is suitably stable for shipment at ambient temperature without any effect on the assigned values. Once reconstituted, diluted or aliquoted, users should determine the stability of the material according to their own method of preparation, storage and use. Users who have data supporting any deterioration in the characteristics of any reference preparation are encouraged to contact Creative Biomart. |
Storage : | For economy of use, it is recommended that the solution be sub divided into several small aliquots and stored at -40°C or below. Unopened ampoules should be stored at –20°C. Please note: because of the inherent stability of lyophilized material, Creative Biomart may ship these materials at ambient temperature. |
Tag : | Non |
Publication : |
TGF-β1 Induces EMT in Bovine Mammary Epithelial Cells Through the TGFβ1/Smad Signaling Pathway. (2017)
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Gene Name : | TGFB1 transforming growth factor, beta 1 [ Bos taurus ]; |
Official Symbol : | TGFB1 |
Synonyms : | transforming growth factor beta-1TGF-beta-1; transforming growth factor-beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease) |
Gene ID : | 282089 |
mRNA Refseq : | NM_001166068 |
Protein Refseq : | NP_001159540 |
UniProt ID : | P18341 |
Chromosome Location : | chromosome: 18 |
Pathway : | Adipogenesis, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem |
Function : | growth factor activity; protein binding; type II transforming growth factor beta receptor binding |
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Customer Reviews (3)
Write a reviewThe impressive performance of the TGFB1 protein both in ELISA assays and protein electron microscopy structure analysis makes it a highly versatile and recommended choice for scientists across various disciplines.
Its reliability and efficacy in generating high-quality data make it an indispensable tool in the quest for unraveling the mysteries of protein structure and function.
The TGFB1 protein's excellent performance in ELISA ensures accurate and reproducible results, enhancing the reliability of experimental data.
Q&As (5)
Ask a questionTGFB1 stimulates the activity of cells involved in bone formation (osteoblasts) and plays a role in regulating bone resorption by influencing osteoclast function.
Potential side effects of anti-TGFB1 therapies may include immune system suppression, gastrointestinal issues, and skin reactions.
TGFB1 levels have been studied as potential biomarkers for diseases like cancer and fibrosis, aiding in diagnosis and monitoring disease progression.
TGFB1 plays a critical role in wound healing by stimulating the formation of new blood vessels, promoting the production of extracellular matrix, and aiding in the migration of cells to the wound site.
TGFB1 can induce the production of excessive extracellular matrix proteins, leading to tissue scarring and fibrosis in organs such as the liver, lung, and kidneys.
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