COX Activity Assay Kit
Cat.No. : | Kit-0252 |
Product Overview : | COX Activity Assay Kit measures the peroxidase activity of COX. The peroxidase activity is assayed colorimetrically by monitoring the appearance of oxidized N,N,N",N"-tetramethyl-p-phenylenediamine (TMPD) at 590 nm. It can be used with both crude (cell lysates/tissue homogenates) and purified enzyme preparations. The kit includes isozymespecific inhibitors for distinguishing COX-2 activity from COX-1 activity. |
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Storage : | Stability: 1 year;Storage: -80°C;This kit will perform as specified if stored as directed and used before the expiration date indicated on the outside of the box. |
Products Types
◆ Assay kits | ||
Kit-0256 | Cyclooxygenase 1 Inhibitor Screening Fluorometric Kit | +Inquiry |
Kit-1941 | COX Colorimetric Inhibitor Screening Assay Kit | +Inquiry |
Kit-0253 | COX Fluorescent Activity Assay Kit | +Inquiry |
Kit-0254 | Cyclooxygenase Activity Luminometric Assay Kit | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionNonsteroidal anti-inflammatory drugs (NSAIDs) are inhibitors of COX, including aspirin, ibuprofen, indomethacin, etc. These drugs exert anti-inflammatory, analgesic, and antipyretic effects by inhibiting the activity of COX and reducing the synthesis of prostaglandins.
Drugs targeting COX have applications in the treatment of inflammatory diseases (such as arthritis, gout, etc.), pain (such as postoperative pain, toothache, etc.), and cardiovascular diseases (such as prevention of thrombosis).
People who need to be cautious about the use of COX-specific drugs mainly include the elderly, pregnant women, patients with gastrointestinal diseases or cardiovascular diseases, etc. These people may be more sensitive to the side effects of the drug and need to be used under the guidance of a doctor.
Inhibition of COX may bring some side effects such as gastrointestinal bleeding, ulcers, cardiovascular events, etc. This is because inhibition of COX affects physiological prostaglandin synthesis, which in turn interferes with gastrointestinal mucosal protection and platelet function.
There are two main subtypes of COX: COX-1 and COX-2. The main difference between them is the expression distribution and function. COX-1 is expressed in most tissues and is involved in the maintenance of tissue homeostasis and physiological functions, while COX-2 is mainly expressed in the site of inflammation and injury, and is involved in inflammatory response and pain processes.
Evaluating the efficacy and safety of drugs targeting COX can be done through methods such as clinical trials and drug monitoring. Clinical trials can evaluate the efficacy and incidence of side effects of drugs, while drug monitoring can monitor the safety and effectiveness of drugs in actual use.
Customer Reviews (3)
Write a reviewCOX is stable under a wide range of experimental conditions, making it ideal for a wide range of applications.
纯度高,可以长期保存。
High sensitivity, small amounts can be used to successfully complete experiments.
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