||The interleukin-18 receptor 1 (IL-18R1) is a cytokine receptor of the immunoglobulin superfamily. IL18R1 is also known as IL-18Rα, CDw218a (cluster of differentiation w218a), IL-1Rrp, and IL-1R family member. IL-18R1 specifically binds to interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL-18Rα is expressed on Th1 cells, NK cell subset, neutrophils and IL-12-stimulated tonsillar B cells. By itself, IL-18Rα binds IL-18 with low affinity and when complexed with IL-18Rβ chain binds IL-18 with high affinity. The proinflammatory cytokine IL-18 and its receptor complex play an important role in the innate and autoimmune responses.
||The predicted molecular weight of Recombinant Human IL-18 Rα is Mr 63 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 95-105 kDa.
|State Of Matter:
||>95% by SDS Page and analyzed by silver stain.
||<1.0 EU/µg as determined by the LAL method.
|Storage And Stability:
||This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.