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Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1)

Cat. No. : LTA-5067H
roduct Overview : Recombinant human LTAwas expressed in Hi-5 Insect cells and purified by using SDS PAGE and HPLC.
Description : LTA is a potentmediator of inflammatory and immune responses. It belongs to the TNFsuperfamily of ligands and signals through TNFR1 and TNFR2. LTA is producedby activated T and B lymphocytes, and has similar activities to TNF-alpha.Like TNF-alpha, LTA is involved in the regulation of various biologicalprocesses incuding cell proliferation, differentiation, apoptosis, lipidmetabolism, coagulation, and neurotransmission. LTA is secreted as a solublepolypeptide, but can form heterotrimers with lymphotoxin-beta, whicheffectively anchors the LTA to the cell surface. LTA is cytotoxic to a widerange of tumor cells.
Source : Human
Host : Hi-5 Insect cells
Form : Lyophilizedfrom 10mM Na3PO4, pH 7.0, with 50 mM NaCl. Reconstitute in Water to aconcentration of 0.1-1.0 mg/ml.
Purity : >98% pure by SDSPAGE and HPLC
Sequence : Region of TNF betaprotein corresponding to amino acids GVGLTPSAAQ TARQHPKMHL AHSTLKPAAHLIGDPSKQNS LLWRANTDRA FLQDGFSLSN NSLLVPTSGI YFVYSQVVFS GKAYSPKATS SPLYLAHEVQLFSSQYPFHV PLLSSQKMVY PGLQEPWLHS MYHGAAFQLT QGDQLSTHTD GIPHLVLSPS TVFFGAFAL.
Molecular Mass : 18.6 kDa
Applications : Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
Storage : Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : LTA
Gene Name : LTAlymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ]
Synonyms : LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB;TNFSF1; lymphotoxin-alpha; LT-alpha; TNF-beta; OTTHUMP00000029184;OTTHUMP00000165897; tumor necrosis factor beta; tumor necrosis factor ligandsuperfamily member 1
Gene ID : 4049
mRNA Refseq : NM_000595
Protein Refseq : NP_000586
MIM : 153440
UniProt ID : P01374
Chromosome Location : 6p21.3
Pathway : Apoptosis;Cytokine-cytokine receptor interaction; HTLV-I infection; Herpes simplexinfection; IL2 signaling events mediated by STAT5; IL4-mediated signalingevents; Type I diabetes mellitus
Function : cytokineactivity; receptor binding; tumor necrosis factor receptor binding

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