Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1)
Cat.No. : | LTA-5067H |
- Specification
- Gene Information
- Related Products
Cat. No. : | LTA-5067H |
roduct Overview : | Recombinant human LTAwas expressed in Hi-5 Insect cells and purified by using SDS PAGE and HPLC. |
Description : | LTA is a potentmediator of inflammatory and immune responses. It belongs to the TNFsuperfamily of ligands and signals through TNFR1 and TNFR2. LTA is producedby activated T and B lymphocytes, and has similar activities to TNF-alpha.Like TNF-alpha, LTA is involved in the regulation of various biologicalprocesses incuding cell proliferation, differentiation, apoptosis, lipidmetabolism, coagulation, and neurotransmission. LTA is secreted as a solublepolypeptide, but can form heterotrimers with lymphotoxin-beta, whicheffectively anchors the LTA to the cell surface. LTA is cytotoxic to a widerange of tumor cells. |
Source : | Human |
Host : | Hi-5 Insect cells |
Form : | Lyophilizedfrom 10mM Na3PO4, pH 7.0, with 50 mM NaCl. Reconstitute in Water to aconcentration of 0.1-1.0 mg/ml. |
Purity : | >98% pure by SDSPAGE and HPLC |
Sequence : | Region of TNF betaprotein corresponding to amino acids GVGLTPSAAQ TARQHPKMHL AHSTLKPAAHLIGDPSKQNS LLWRANTDRA FLQDGFSLSN NSLLVPTSGI YFVYSQVVFS GKAYSPKATS SPLYLAHEVQLFSSQYPFHV PLLSSQKMVY PGLQEPWLHS MYHGAAFQLT QGDQLSTHTD GIPHLVLSPS TVFFGAFAL. |
Molecular Mass : | 18.6 kDa |
Applications : | Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions. |
Storage : | Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | LTA |
Gene Name : | LTAlymphotoxin alpha (TNF superfamily, member 1) [ Homo sapiens ] |
Synonyms : | LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB;TNFSF1; lymphotoxin-alpha; LT-alpha; TNF-beta; OTTHUMP00000029184;OTTHUMP00000165897; tumor necrosis factor beta; tumor necrosis factor ligandsuperfamily member 1 |
Gene ID : | 4049 |
mRNA Refseq : | NM_000595 |
Protein Refseq : | NP_000586 |
MIM : | 153440 |
UniProt ID : | P01374 |
Chromosome Location : | 6p21.3 |
Pathway : | Apoptosis;Cytokine-cytokine receptor interaction; HTLV-I infection; Herpes simplexinfection; IL2 signaling events mediated by STAT5; IL4-mediated signalingevents; Type I diabetes mellitus |
Function : | cytokineactivity; receptor binding; tumor necrosis factor receptor binding |
Products Types
◆ Native Protein | ||
LTA-18S | Native S. aureus LTA Protein | +Inquiry |
LTA-14S | Native S. aureus LTA Protein | +Inquiry |
LTA-15B | Native Bacillus subtilis LTA Protein | +Inquiry |
◆ Lysates | ||
LTA-9167HCL | Recombinant Human LTA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionLTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.
Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.
Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.
LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.
LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.
Customer Reviews (3)
Write a reviewIts purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.
Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.
The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.
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