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Recombinant Human Ubiquitin-Conjugating Enzyme E2K, His-tagged

Cat.No. : UBE2K-1790H
Product Overview : Recombinant humanUBE2K protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
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Cat. No. : UBE2K-1790H
Description : Ubiquitin-conjugatingenzyme E2 K isoform 1, also known as UBE2K, is a member of theubiquitin-conjugating enzymes family. These enzymes participate in a varietyof cellular processes, including selective protein degradation, DNA repair,cell cycle control, and sporulation. In this mechanism, the ATP-coupledactivation and subsequent ligation of ubiquitin are catalyzed by separateenzymes functionally linked by ubiquitin carrier protein UBC1. Also, UBE2K isreportedly involved in Alzheimer"s disease, Huntington"s disease and proteinprocessing through its interaction with amyloid-?, huntingtin, and MHC-heavychain proteins.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Suppliedas a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 1mM DTT, 10% glyceroland 50mM NaCl.
Purity : > 95% by SDS -PAGE
Sequence : 1-200 amino acids:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMANI AVQRIKREFK EVLKSEETSK NQIKVDLVDENFTELRGEIA GPPDTPYEGG RYQLEIKIPE TYPFNPPKVR FITKIWHPNI SSVTGAICLD ILKDQWAAAMTLRTVLLSLQ ALLAAAEPDD PQDAVVANQY KQNPEMFKQT ARLWAHVYAG APVSSPEYTK KIENLCAMGFDRNA
Molecular Mass : 26.5 kDa(236aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appearhigher).
Applications : SDS-PAGE
Storage : Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : UBE2K
Gene Name : UBE2K ubiquitin-conjugatingenzyme E2K [ Homo sapiens ]
Synonyms : UBE2K; ubiquitin-conjugating enzyme E2K; LIG; HIP2; HYPG; UBC1;E2-25K; DKFZp564C1216; DKFZp686J24237; HIP-2; E2(25K); OTTHUMP00000218439;OTTHUMP00000218440; OTTHUMP00000218441; OTTHUMP00000218442; ubiquitin-proteinligase; ubiquitin carrier protein; huntingtin interacting protein 2;huntingtin-interacting protein 2; ubiquitin-conjugating enzyme E2-25K;ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA;ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); NP_001104582.1; NP_001104583.1;NP_005330.1; EC 6.3.2.19
Gene ID : 3093
mRNA Refseq : NM_001111112
Protein Refseq : NP_001104582
MIM : 602846
UniProt ID : C9JGP1
Chromosome Location : 4p14
Pathway : AdaptiveImmunity Signaling; Antigen processing; Class I MHC mediated antigenprocessing & presentation; Immune System; Innate Immunity Signaling;Negative regulators of RIG-I/MDA5 signaling; RIG-I/MDA5 mediated induction ofIFN-alpha/beta pathways; Ubiquitin mediated proteolysis
Function : ATPbinding; acid-amino acid ligase activity; ligase activity; nucleotidebinding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity;ubiquitin-ubiquitin ligase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is UBE2K a potential biomarker for any diseases? 06/14/2021

UBE2K expression levels are being investigated as potential biomarkers for certain cancers and neurodegenerative diseases, offering insights into disease progression and prognosis.

How does UBE2K influence protein quality control in cells? 03/04/2021

UBE2K is involved in the ubiquitination of misfolded or damaged proteins, marking them for degradation, thus contributing to protein quality control mechanisms within cells.

Can targeting UBE2K be a strategy for personalized medicine? 05/03/2020

The potential role of UBE2K as a therapeutic target suggests that personalized medicine approaches could be developed based on the specific molecular characteristics of a patient's disease.

Are there any known genetic variations in the UBE2K gene associated with diseases? 06/08/2019

Genetic variations in the UBE2K gene have been explored for associations with certain diseases, providing insights into the genetic basis of UBE2K-related disorders.

How does UBE2K contribute to the immune response? 06/28/2017

UBE2K is involved in the ubiquitination of proteins in the immune signaling pathways, influencing the immune response and inflammation.

Customer Reviews (3)

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Reviews
12/05/2022

    This protein is known for its exceptional quality and purity, providing reliable and consistent results.

    12/20/2021

      Its high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.

      10/13/2016

        The UBE2K protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.

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