Recombinant Human Ubiquitin-Conjugating Enzyme E2K, His-tagged
Cat.No. : | UBE2K-1790H |
Product Overview : | Recombinant humanUBE2K protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | UBE2K-1790H |
Description : | Ubiquitin-conjugatingenzyme E2 K isoform 1, also known as UBE2K, is a member of theubiquitin-conjugating enzymes family. These enzymes participate in a varietyof cellular processes, including selective protein degradation, DNA repair,cell cycle control, and sporulation. In this mechanism, the ATP-coupledactivation and subsequent ligation of ubiquitin are catalyzed by separateenzymes functionally linked by ubiquitin carrier protein UBC1. Also, UBE2K isreportedly involved in Alzheimer"s disease, Huntington"s disease and proteinprocessing through its interaction with amyloid-?, huntingtin, and MHC-heavychain proteins. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Suppliedas a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 1mM DTT, 10% glyceroland 50mM NaCl. |
Purity : | > 95% by SDS -PAGE |
Sequence : | 1-200 amino acids:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMANI AVQRIKREFK EVLKSEETSK NQIKVDLVDENFTELRGEIA GPPDTPYEGG RYQLEIKIPE TYPFNPPKVR FITKIWHPNI SSVTGAICLD ILKDQWAAAMTLRTVLLSLQ ALLAAAEPDD PQDAVVANQY KQNPEMFKQT ARLWAHVYAG APVSSPEYTK KIENLCAMGFDRNA |
Molecular Mass : | 26.5 kDa(236aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appearhigher). |
Applications : | SDS-PAGE |
Storage : | Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
OfficialSymbol : | UBE2K |
Gene Name : | UBE2K ubiquitin-conjugatingenzyme E2K [ Homo sapiens ] |
Synonyms : | UBE2K; ubiquitin-conjugating enzyme E2K; LIG; HIP2; HYPG; UBC1;E2-25K; DKFZp564C1216; DKFZp686J24237; HIP-2; E2(25K); OTTHUMP00000218439;OTTHUMP00000218440; OTTHUMP00000218441; OTTHUMP00000218442; ubiquitin-proteinligase; ubiquitin carrier protein; huntingtin interacting protein 2;huntingtin-interacting protein 2; ubiquitin-conjugating enzyme E2-25K;ubiquitin-conjugating enzyme E2(25K); ubiquitin-conjugating enzyme E2-25 KDA;ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); NP_001104582.1; NP_001104583.1;NP_005330.1; EC 6.3.2.19 |
Gene ID : | 3093 |
mRNA Refseq : | NM_001111112 |
Protein Refseq : | NP_001104582 |
MIM : | 602846 |
UniProt ID : | C9JGP1 |
Chromosome Location : | 4p14 |
Pathway : | AdaptiveImmunity Signaling; Antigen processing; Class I MHC mediated antigenprocessing & presentation; Immune System; Innate Immunity Signaling;Negative regulators of RIG-I/MDA5 signaling; RIG-I/MDA5 mediated induction ofIFN-alpha/beta pathways; Ubiquitin mediated proteolysis |
Function : | ATPbinding; acid-amino acid ligase activity; ligase activity; nucleotidebinding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity;ubiquitin-ubiquitin ligase activity |
Products Types
◆ Recombinant Protein | ||
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UBE2K-4758H | Recombinant Human UBE2K Protein, GST-tagged | +Inquiry |
Ube2k-6791M | Recombinant Mouse Ube2k Protein, Myc/DDK-tagged | +Inquiry |
UBE2K-9831M | Recombinant Mouse UBE2K Protein, His (Fc)-Avi-tagged | +Inquiry |
UBE2K-4876R | Recombinant Rhesus Macaque UBE2K Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
UBE2K-571HCL | Recombinant Human UBE2K 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionUBE2K expression levels are being investigated as potential biomarkers for certain cancers and neurodegenerative diseases, offering insights into disease progression and prognosis.
UBE2K is involved in the ubiquitination of misfolded or damaged proteins, marking them for degradation, thus contributing to protein quality control mechanisms within cells.
The potential role of UBE2K as a therapeutic target suggests that personalized medicine approaches could be developed based on the specific molecular characteristics of a patient's disease.
Genetic variations in the UBE2K gene have been explored for associations with certain diseases, providing insights into the genetic basis of UBE2K-related disorders.
UBE2K is involved in the ubiquitination of proteins in the immune signaling pathways, influencing the immune response and inflammation.
Customer Reviews (3)
Write a reviewThis protein is known for its exceptional quality and purity, providing reliable and consistent results.
Its high specificity and functional integrity ensure accurate and reproducible data, allowing researchers to draw meaningful conclusions from their experiments.
The UBE2K protein offers numerous advantages in trials and research experiments, making it an excellent choice for researchers.
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