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| Cat. No.: | SERPINE1-5117H |
| Product Overview: | Recombinant human SERPINE1was expressed in E. coli. |
| Description: | SERPINE1 is amember of the serpin family of serine protease inhibitors, and is the primaryinhibitor of urokinase and tissue plasminogen activator (tPA). SERPINE1 is expressed predominantly in adipose,liver and vascular tissues, and is also produced by certain tumor cells.Elevated levels of SERPINE1 are associatedwith obesity, diabetes and cardiovascular disease, and increased productionof SERPINE1 is induced by various obesityrelated factors such as TNFa, glucose, insulin, and very-low-densitylipoprotein. The obesity related elevation of SERPINE1levels along with the consequential deficiency in plasminogen activators canlead directly to increased risk of thrombosis and other coronary diseases. |
| Concentration: | 0.1-1.0 mg/ml |
| Source: | Human |
| Host: | E. coli |
| Form: | Lyophilizedfrom 50mM CH3COONa, pH 5.5, with 100mM NaCl. Reconstitute in water to aconcentration of 0.1-1.0 mg/ml. |
| Purity: | > 98% pure by SDSPAGE and HPLC |
| Sequence: | Region of SERPINE1protein corresponding to amino acids: MVHHPPSYVA HLASDFGVRV FQQVAQASKDRNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFVQRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNALYFNGQWKTPF PDSST |
| Molecular Mass: | 42.7 kDa |
| Applications: | Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions. |
| Storage: | Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
| OfficialSymbol: | SERPINE1 |
| Gene Name: | SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ] |
| Synonyms: | SERPINE1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1; PAI; PAI1; PAI-1; PLANH1; serine (or cysteine)proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type1), member 1; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; Serpin E1; OTTHUMP00000211478; OTTHUMP00000211479 |
| Gene ID: | 5054 |
| mRNA Refseq: | NM_000602 |
| Protein Refseq: | NP_000593 |
| MIM: | 173360 |
| UniProt ID: | P05121 |
| Chromosome Location: | 7q21.3-q22 |
| Pathway: | Complement and coagulationcascades; Hemostasis |
| Function: | peptidase inhibitor activity;protease binding; protein binding; serine-type endopeptidase activity;serine-type endopeptidase inhibitor activity |
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