Recombinant Human Vascular Endothelial Growth Factor B

• Cat.No.: VEGFB-640H
• Product Overview: Recombinant human VEGFB proteinwas expressed in E. coli.

Specification

• Cat. No.: VEGFB-640H
• Description: VEGFB, a member ofthe VEGF family, is a potent growth and antigenic cytokine. It promotes DNAsynthesis in endothelial cells, helps regulate angiogenesis and vascularpermeability, and inhibits apoptosis in certain smooth muscle cells andneurons. VEGFB is expressed in all tissues except the liver. It forms cellsurfaced-associated disulfide linked homodynes and can form heterodynes withVEGF-A. There are two known isoforms, formed by alternative splicing, whichhave been designated VEGFB167 and VEGFB186. Both forms have identicalamino-terminal sequences encoding a "cytokine knot" like structural motif,but differ in their carboxyl-terminal domains.
• Concentration: 1.0-2.0 ug/ml
• Source: Human
• Host: E. coli
• Form: Suppliedas a lyophilized powder.
• Purity: > 98% pure by SDSPAGE and HPLC
• Sequence: Region of VEGFBprotein corresponding to amino acids: PVSQPDAPGH QRKVVSWIDV YTRATCQPREVVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQCECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR
• Applications: Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
• Storage: Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: VEGFB

Gene Information

• Gene Name: VEGFB vascular endothelialgrowth factor B [ Homo sapiens ]
• Synonyms: VEGFB; vascularendothelial growth factor B; VRF; VEGFL; Vascular endothelial growth factor B; VEGF-B; VEGF-relatedfactor
• Gene ID: 7423
• mRNA Refseq: NM_003377
• Protein Refseq: NP_003368
• MIM: 601398
• UniProt ID: P49765
• Chromosome Location: 11q13
• Pathway: Cytokine-cytokine receptorinteraction; Focal adhesion; Pancreatic cancer; Renal cell carcinoma; mTORsignaling pathway; Hemostasis; Signaling by VEGF
• Function: chemoattractant activity; growth factor activity; heparin binding; protein binding;vascular endothelial growth factor receptor binding; proteinheterodimerization activity; protein homodimerization activity