Recombinant Human PTPRM, GST-tagged
Cat.No. : | PTPRM-1861H |
Product Overview : | Recombinant humanPTPRM was expressed in anE.coliexpression system using a N-terminal GST tag. MW=56.2kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PTPRM-1861H |
Description : | PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity. |
Source : | E.coli. |
Purity : | > 95% by SDS-PAGE. |
Specific Activity : | 680 U/ug. One unit will hydrolyze 1 pmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. |
Application : | Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione. |
Stability : | >6 months at –80°C. |
Gene Name : | PTPRM protein tyrosine phosphatase, receptor type, M [ Homo sapiens ] |
Synonyms : | PTPRM; protein tyrosine phosphatase, receptor type, M; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; EC 3.1.3.48 |
Gene ID : | 5797 |
mRNA Refseq : | NM_001105244 |
Protein Refseq : | NP_001098714 |
MIM : | 176888 |
UniProt ID : | P28827 |
Chromosome Location : | 18p11.2 |
Pathway : | Adherens junction; Cell adhesion molecules (CAMs) |
Function : | cadherin binding; hydrolase activity; protein binding; receptor activity; transmembrane receptor protein tyrosine phosphatase activity |
Products Types
◆ Recombinant Protein | ||
PTPRM-5469H | Recombinant Human Protein Tyrosine Phosphatase, Receptor Type, M | +Inquiry |
PTPRM-7288M | Recombinant Mouse PTPRM Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPRM-7017H | Recombinant Human PTPRM , GST-tagged | +Inquiry |
PTPRM-382H | Recombinant Human PTPRM, GST-tagged | +Inquiry |
PTPRM-6108H | Recombinant Human PTPRM Protein (Thr1197-Ser1403), N-His tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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