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Recombinant Human Colony Stimulating Factor 1 (macrophage)

Cat.No. : CSF1-339H
Product Overview : Recombinant human CSF1was expressed in E. coli and purified recombinant Human CSF1 protein.
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Cat. No. : CSF1-339H
Description : CSF1 is a potenthematopoietic factor produced by a variety of cells including lymphocytes,monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is akey regulator of cellular proliferation, differentiation, and survival ofblood monocytes, tissue macrophages and their progenitor cells. CSF1 has beenshown to play important roles in modulating dermal thickness, and male andfemale fertility. CSF1 is clinically used in the treatment of infection,malignancies and atherosclerosis. It facilitates hematopoietic recovery afterbone marrow transplantation.
Source : Human
Host : E. coli
Form : Supplied as alyophilized powder.
Purity : > 98% pure by SDSPAGE and HPLC
Sequence : Region of M-CSFprotein corresponding to amino acids MEVSEHCSHM IGNGHLQILQ QLIDSQMETACLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNEACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP.
Molecular Mass : 18.1 kDa
Applications : Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions.
Storage : Store at 4 deg Cuntil reconstitution. Following reconstitution aliquot and freeze at -20 degC for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : CSF1
Gene Name : CSF1 colony stimulating factor 1(macrophage) [ Homo sapiens ]
Synonyms : CSF1; colony stimulating factor1 (macrophage); MCSF; MGC31930; colony stimulating factor 1;OTTHUMP00000013363; OTTHUMP00000013364; macrophage colony stimulating factor;M-CSF; CSF-1; Lanimostim; OTTHUMP00000013362
Gene ID : 1435
mRNA Refseq : NM_000757
Protein Refseq : NP_000748
MIM : 120420
UniProt ID : P09603
Chromosome Location : 1p21-p13
Pathway : Cytokine-cytokine receptorinteraction; Hematopoietic cell lineage; Osteoclastdifferentiation; Rheumatoid arthritis; Signaling events mediated by PTP1B;Signaling events mediated by TCPTP
Function : cytokine activity; growthfactor activity; macrophage colony stimulating factor receptor binding;protein binding; protein homodimerization activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CSF1 affect cancer progression? 09/20/2022

CSF1 is implicated in tumor-associated macrophages, influencing tumor growth, invasion, and the tumor microenvironment.

What are the potential side effects of CSF1 therapy? 07/11/2022

Side effects may include immune-related adverse events, inflammation, and alterations in white blood cell counts.

Can CSF1 therapy be combined with other treatments? 08/26/2020

Yes, there is ongoing research on combining CSF1-targeted therapies with other immunotherapies or conventional treatments to enhance efficacy.

What are the challenges in developing CSF1-based therapies? 09/26/2019

Challenges include maintaining the balance of immune responses, potential off-target effects, and variability in patient responses.

In what ways is CSF1 being researched for neurological disorders? 10/01/2018

Studies are exploring its role in neuroinflammation, neuroprotection, and potential therapeutic interventions for conditions like Alzheimer's disease.

Customer Reviews (3)

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Reviews
10/30/2017

    The CSF1 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.

    03/10/2017

      With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.

      06/09/2016

        Whether it is for investigating cellular pathways, studying protein functions, or exploring signaling cascades, the CSF1 protein offers unparalleled versatility and performance.

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