Native Human Apolipoprotein A-I

• Cat.No.: APOA1-5301H
• Product Overview: Native Human APOA1is a single polypeptide chain containing 245 amino acids. Its molecular weight is 28300 Dalton.

Specification

• Cat. No.: APOA1-5301H
• Description: APOA1 is a proteinthat in humans is encoded by the APOA1 gene. It has a specific role in lipidmetabolism. Apolipoprotein A-I is the major protein component of high densitylipoprotein (HDL) in plasma. Chylomicrons secreted from the intestinalenterocyte also contain ApoA1 but it is quickly transferred to HDL in thebloodstream. The protein promotes cholesterol efflux from tissues to theliver for excretion. It is a cofactor for lecithin cholesterolacyltransferase(LCAT) which is responsible for the formation of most plasma cholesterylesters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor,and thus may have an anticlotting effect. Defects in the gene encoding it areassociated with HDL deficiencies, including Tangier disease, and withsystemic non-neuropathic amyloidosis. It has an approximate molecular weight28 KDa.
• Form: 0.2 μm sterilefiltered liquid in Tris-HCl + NaCl, pH 7.4 + disodium EDTA + sodium azide.Precaution: Sodium azide is a poisonous and hazardous substance which shouldbe handled by trained staff only.
• Source: Human plasm
• Concentration: > 0.9 mg/ml
• MolecularWeight: 28.3 kDa
• Purity: > 97% asdetermined by SDS-PAGE analysis.
• Storage: Store at 2-4°C forshort term storage and -20°C to -80°C for long term storage. Avoid repeatedfreeze-thaw cycles.
• OfficialSymbol: APOA1

Gene Information

• Gene Name: APOA1 apolipoprotein A-I [ Homo sapiens ]
• Synonyms: APOA1;apolipoprotein A-I; MGC117399; OTTHUMP00000069348; OTTHUMP00000069347;OTTHUMP00000069346; apo-AI; apoA-I; OTTHUMP00000043268; Apolipoprotein A1;ALP-1; APOA; APOA-1; Apo-AI; BRP-14; LTW-1; LVTW-1; SEP-1; SEP-2;Apolipoprotein A-I; ApoA-I
• Gene ID: 335
• mRNA Refseq: NM_000039
• Protein Refseq: NP_000030
• MIM: 107680
• UniProt ID: P02647
• Chromosome Location: 11q23-q24
• Pathway: ABC-family proteinsmediated transport; ABCA transporters in lipid homeostasis; Africantrypanosomiasis; Amyloids; Chylomicron-mediated lipid transport; FOXA2 andFOXA3 transcription factor networks; Fat digestion and absorption; Fatty acid,triacylglycerol, and ketone body metabolism; Folate Metabolism; HDL-mediatedlipid transport; Hemostasis; Lipid digestion; Lipoprotein metabolism;Metabolism of lipids and lipoproteins; PPAR signaling pathway; Plateletactivation; Statin Pathway
• Function: apolipoprotein A-Ireceptor binding; apolipoprotein receptor binding; beta-amyloid binding;cholesterol binding; contributes_to cholesterol transporter activity;cholesterol transporter activity; enzyme binding; high-density lipoproteinparticle binding; high-density lipoprotein particle receptor binding;identical protein binding; lipid transporter activity;phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipidbinding; protein binding