"ADRBK1" Related Products

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Recombinant Human Adrenergic, Beta, Receptor Kinase 1, His-tagged

Cat. No. : ADRBK1-357H
Product Overview : Recombinant humanADRBK1 with His Tag is a serine/threonine kinase.
Description : Many of the Gprotein-coupled receptors are known tobe phosphorylated by G protein-dependent receptor kinases (GRKs). ADRBK1 (also referred to as βARK or BARK) is aserine/threonine intracellular kinase. It is activated by PKA and its targetis the beta adrenergic receptor. It is one method by which the cell willdesensitize itself from epinephrine overstimulation.
Source : Insect cells
Species : Human
Form : Liquid in 50 mMTris-HCl, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02%. Triton X-100 + 2 mM DTT+ 50% glycerol.
Molecular Weight : 82.3 kDa
Concentration : 0.5 mg/ml
Purity : > 95% asdetermined by SDS-PAGE analysis.
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : ADRBK1
PDB rendering basedon 1bak. :

Gene Name : ADRBK1 adrenergic, beta, receptorkinase 1 [ Homo sapiens ]
Synonyms : ADRBK1; adrenergic,beta, receptor kinase 1; GRK2; BARK1; FLJ16718; BETA-ARK1; beta-adrenergicreceptor kinase 1; beta-ARK-1; OTTHUMP00000235171; G-protein coupled receptorkinase 2; EC 2.7.11.15; BETA-ARK1; EC 2.7.11
Gene ID : 156
mRNA Refseq : NM_001619
Protein Refseq : NP_001610
MIM : 109635
UniProt ID : P25098
Chromosome Location : 11q13.1
Pathway : CXCR4-mediatedsignaling events; Ca-dependent events; CaM pathway; Calmodulin inducedevents; Chemokine signaling pathway; DAG and IP3 signaling; Downstream signaltransduction; EGFR interacts with phospholipase C-gamma; Endocytosis; GPCRdownstream signaling; NGF signalling via TRKA from the plasma membrane;Opioid Signalling; PLC beta mediated events; Phospholipase C-mediatedcascade; Signaling by EGFR; Signalling by NGF; Thromboxane A2 receptorsignaling
Function : ATP binding; Edg-2lysophosphatidic acid receptor binding; G-protein coupled receptor kinaseactivity; alpha-2A adrenergic receptor binding; beta-adrenergic receptorkinase activity; nucleotide binding; protein binding; protein kinaseactivity; signal transducer activity

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