Recombinant Human Adrenergic, Beta, Receptor Kinase 1, His-tagged

• Cat.No.: ADRBK1-357H
• Product Overview: Recombinant humanADRBK1 with His Tag is a serine/threonine kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: Many of the Gprotein-coupled receptors are known tobe phosphorylated by G protein-dependent receptor kinases (GRKs). ADRBK1 (also referred to as βARK or BARK) is aserine/threonine intracellular kinase. It is activated by PKA and its targetis the beta adrenergic receptor. It is one method by which the cell willdesensitize itself from epinephrine overstimulation.
• Form: Liquid in 50 mMTris-HCl, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02%. Triton X-100 + 2 mM DTT+ 50% glycerol.
• Molecular Weight: 82.3 kDa
• Concentration: 0.5 mg/ml
• Purity: > 95% asdetermined by SDS-PAGE analysis.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: ADRBK1

Gene Information

• Gene Name: ADRBK1 adrenergic, beta, receptorkinase 1 [ Homo sapiens ]
• Synonyms: ADRBK1; adrenergic,beta, receptor kinase 1; GRK2; BARK1; FLJ16718; BETA-ARK1; beta-adrenergicreceptor kinase 1; beta-ARK-1; OTTHUMP00000235171; G-protein coupled receptorkinase 2; EC 2.7.11.15; BETA-ARK1; EC 2.7.11
• Gene ID: 156
• mRNA Refseq: NM_001619
• Protein Refseq: NP_001610
• MIM: 109635
• UniProt ID: P25098
• Chromosome Location: 11q13.1
• Pathway: CXCR4-mediatedsignaling events; Ca-dependent events; CaM pathway; Calmodulin inducedevents; Chemokine signaling pathway; DAG and IP3 signaling; Downstream signaltransduction; EGFR interacts with phospholipase C-gamma; Endocytosis; GPCRdownstream signaling; NGF signalling via TRKA from the plasma membrane;Opioid Signalling; PLC beta mediated events; Phospholipase C-mediatedcascade; Signaling by EGFR; Signalling by NGF; Thromboxane A2 receptorsignaling
• Function: ATP binding; Edg-2lysophosphatidic acid receptor binding; G-protein coupled receptor kinaseactivity; alpha-2A adrenergic receptor binding; beta-adrenergic receptorkinase activity; nucleotide binding; protein binding; protein kinaseactivity; signal transducer activity