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Recombinant Human Integrin, Beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12), GST-tagged

Cat. No.: ITGB1-1181H
Product Overview: Recombinant human ITGB1is a 130 kDa transmembrane glycoprotein including a GST Tag, which isexpressed in E. coli.
Description: Integrin beta1(ITGB1), also known as CD29, is a 130 kDa transmembrane glycoprotein thatforms noncovalent complexes with various Integrin alpha subunits (includingalpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known asCD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form thefunctional receptors that bind to specific extracellular matrix proteins.Integrin receptors are involved in the regulation of a variety of importantbiological functions, including embryonic development, wound repair, hemostasis,and prevention of programmed cell death. They are also implicated in abnormalpathological states such as tumor directed angiogenesis, tumor cell growth,and metastasis. These heterodimeric receptors bridge the cytoplasmic actincytoskeleton with proteins present in the extracellular matrix and/or onadjacent cells. The clustering of integrins on a cell surface leads to theformation of focal contacts. Interactions between integrins and theextracellular matrix lead to activation of signal transduction pathways andregulation of gene expression.
Source: E. coli
Species: Human
Form: Liquid in 50 mMTris-Acetate, pH 7.5 + 1 mM EDTA + 20% Glycerol.
Molecular Weight: 48 kDa
Concentration: 100 µg/mL
Applications: ELISA, InhibitionAssays, Western Blot
Storage: Store at -20°C to-80°C. 1 year. Avoid repeated freeze/thaw cycles.
OfficialSymbol: ITGB1
Gene Name: ITGB1 integrin, beta 1(fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) [Homo sapiens ]
Synonyms: ITGB1; integrin,beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2,MSK12); CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA; integrin beta-1; OTTHUMP00000019420;integrin VLA-4 beta subunit; very late activation protein, beta polypeptide;Fibronectin receptor subunit beta; CD29 antigen
Gene ID: 3688
mRNA Refseq: NM_002211
Protein Refseq: NP_002202
MIM: 135630
UniProt ID: P05556
Chromosome Location: 10p11.2
Pathway: Adaptive ImmuneSystem; Angiopoietin receptor Tie2-mediated signaling; Axon guidance;Bacterial invasion of epithelial cells; CHL1 interactions; Cell surfaceinteractions at the vascular wall; Dilated cardiomyopathy; ECM-receptorinteraction; Hypertrophic cardiomyopathy (HCM); Integrin cell surfaceinteractions; Pathogenic Escherichia coli infection; Reelin signalingpathway; Semaphorin interactions; Toxoplasmosis; VEGFR3 signaling inlymphatic endothelium
Function: actin binding;alpha-actinin binding; collagen binding; fibronectin binding; glycoproteinbinding; integrin binding; laminin binding; peptide binding; proteasebinding; protein binding; protein domain specific binding; proteinheterodimerization activity; protein kinase binding; receptor activity

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