Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C)


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Recombinant Human Insulin-Like Growth Factor 1 (somatomedin C)

IGF1 Related Products

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Cat. No. : IGF1-606H
Product Overview : Recombinant humanIGF1 contains 70 amino acids and a 13 amino acid Histidine-based tag. It hasa predicted molecular mass of 9.3 kDa and migrates with an apparent MW 12 kDain SDS-PAGE.
Description : IGF1 is aprotein that in humans is encoded by the IGF1 gene. IGF1 has also beenreferred to as a sulfation factor and its effects were termed nonsuppressibleinsulin-like activity (NSILA) in the 1970s. IGF1 is a hormone similar inmolecular structure to insulin. It plays an important role in childhoodgrowth and continues to have anabolic effects in adults. A synthetic analogof IGF1, mecasermin is used for the treatment of growth failure.
Source : Hordeum vulgare
Species : Human
Molecular Weight : 12 kDa
Form : Lyophilized from a0.2 sterile filtered solution in 50 mM MES, pH 6.5+100 mM NaCl.
Purity : > 98% asdetermined by SDS-PAGE analysis
Endotoxin Level : < 0.005 ng/ug ofIGF1
Biological Activity : Bioactivity isassayed by measuring the dose dependent effect of human IGF1 on proliferationof FDC-P1 cells, mouse progenitor cells of granulocytes, monocytes andmacrophages. The ED50 for this effect is 10.0 ng/ml.
Specific Activity : 1 x 105U/mg
Reconstitution : Centrifuge vialprior to opening. Add steriledistilled water to the vial to fully solubilize the protein to aconcentration not less than 100 ng/ml.
Storage : Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -20°C witha carrier protein (0.1% HSA or BSA) as a stabilizer for long term storage. Pleasenote that the addition of any carrier protein into this product may produceunwanted endotoxin. This depends upon the particular application employed. Avoidrepeated freeze-thaw cycles.
OfficialSymbol : IGF1
PDBrendering based on 1bqt. :

Gene Name : IGF1 insulin-like growth factor1 (somatomedin C) [ Homo sapiens ]
Synonyms : IGF1; insulin-likegrowth factor 1 (somatomedin C); IGFI; IGF-I; IGF1A; insulin-likegrowth factor 1; MGF; IGF-IA; IGF-IB; somatomedin-C; OTTHUMP00000195080;OTTHUMP00000195081; OTTHUMP00000195082; OTTHUMP00000195083;OTTHUMP00000195084; mechano growth factor; insulin-like growth factor I;insulin-like growth factor IA; insulin-like growth factor IB
Gene ID : 3479
mRNA Refseq : NM_000618
Protein Refseq : NP_000609
MIM : 147440
UniProt ID : P01343
Chromosome Location : 12q22-q23
Pathway : Adipogenesis;Aldosterone-regulated sodium reabsorption; Androgen Receptor SignalingPathway; Apoptosis; Diabetes pathways; Dilated cardiomyopathy; EndochondralOssification; Focal Adhesion; Glioma; Hemostasis; Id Signaling Pathway;Long-term depression; Melanoma; MicroRNAs in cardiomyocyte hypertrophy;Oocyte meiosis
Function : growth factor activity;hormone activity; insulin receptor binding; insulin-like growth factorreceptor binding; integrin binding; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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