Native Human Cathepsin G

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Native Human Cathepsin G

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Cat. No. : CTSG-5327H
Product Overview : Native Human CTSG was expressed in Human Neutrophil.
Description : CTSG, is a serine protease, and a member of thepeptidase S1 protein family, located in the azurophil granules of neutrophils.Studies have shown that CTSG when released from granulocytes binds to NKcells and augments NK cytotoxicity through its protease activity. CTSG has aspecificity similar to that of Chymotrypsin C, and may participate in thekilling and digestion of engulfed pathogens, and in connective tissueremodeling at sites of inflammation. Transcript variants utilizingalternative polyadenylation signals exist for this gene.
Form : Liquid in50 mM Sodium Acetate pH 5.5 + 0.8 M NaCl.
Source : Human Neutrophil
Biological Activity : One unit willhydrolyze one micromole ofSuccinyl-alanine-alanine-proplinephenylalanine-p-nitroanilide per minute at37°C and pH 7.5.
Concentration : Typically > 0.1mg/ml
Storage : Product is stable at -80°Cfor 3 years.
OfficialSymbol : CTSG
Pathways : ACE Inhibitor Pathway; Lysosome; Amoebasis;Diabetes; Neuroactive ligand-receptor interaction; Renin-angiotensin system;Systemic lupus erythematosus
PDBrendering based on 1au8. :

Gene Name : CTSGcathepsin G [ Homo sapiens ]
Synonyms : CTSG; cathepsinG; CG; CATG; MGC23078; OTTHUMP00000178752; EC 3.4.21.20; Cathepsin G
Gene ID : 1511
mRNA Refseq : NM_001911
Protein Refseq : NP_001902
MIM : 116830
UniProt ID : P08311
Chromosome Location : 14q11.2
Function : serine-typeendopeptidase activity; heparin binding; peptidase activity

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