Native Rat Coagulation Factor II
Cat.No. : | F2-5286R |
Product Overview : | Rat F2 isprepared from fresh frozen rat plasma. Purity is determined by SDS PAGE analysis. |
- Specification
- Gene Information
- Related Products
Cat. No. : | F2-5286R |
Description : | F2is proteolytically cleaved to form thrombin in the first step of thecoagulation cascade, which ultimately results in the stemming of blood loss.F2 in turn acts as a serine protease that converts soluble fibrinogen intoinsoluble strands of fibrin, as well as catalyzing many othercoagulation-related reactions. |
Source : | Rat plasma |
Form : | Liquid in 50%Glycero. |
Purity : | > 95% by SDS-PAGEanalysis. |
MolecularWeight : | 72,000 |
Concentration : | 5.0mg/ml |
Storage : | Store at -20°C. |
Pathways : | BloodClotting Cascade; Cell surface interactions at the vascular wall; ClassA/1(Rhodopsin-like receptors); Common Pathway; Complement and CoaqulationCascades; Diabetes pathways; FOXA2 and FOXA3 transcription factor networks; ExtrinsicPathway; Formation of Fibrin Clot (Clotting Cascade); Hemostasis; IntrinsicPathway; Regulation of actin cytoskeleton; Selenium Pathway; SignalTransduction |
Gene Name : | F2coagulation factor II [ Rattus norvegicus] |
Official Symbol : | F2 |
Synonyms : | F2; coagulation factor II; prothrombin; thrombin; coagulationfactor2; EC 3.4.21.5 |
Gene ID : | 29251 |
mRNA Refseq : | NM_022924 |
Protein Refseq : | NP_075213 |
Chromosome Location : | 3q24 |
Function : | peptidase activity; serine-typeendopeptidase activity; calcium ion binding; receptor binding; contributes toreceptor binging; thrombospondin receptor activity |
Products Types
◆ Recombinant Protein | ||
F2-882H | Recombinant Human F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-3610H | Recombinant Human F2 Protein, GST-tagged | +Inquiry |
F2-789H | Recombinant Human F2 Protein | +Inquiry |
F2-1356R | Recombinant Rhesus Macaque F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-907P | Recombinant Pig F2 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
F2-276B | Active Native Bovine α-Thrombin-FPRck (FPR-CMK*) | +Inquiry |
F2-90B | Active Native Bovine Thrombin | +Inquiry |
F2-5401B | Native Bovine Coagulation Factor II (thrombin) | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
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