Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged


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Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged

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Cat. No. : ERBB3-5193H
Product Overview : Recombinant HumanTyrosine Kinase ERBB3 (extracellular domain) is a single, non- glycosylated,fusion polypeptide chain containing Thyrodoxin Tag and His tag. The proteinconsists of 190 amino acids (Met1- Cys190). ERBB3 is expressed in E. coli, MW 34kDa.
Description : Receptortyrosine-protein kinase ERBB3 is an enzyme that in humans is encoded by theERBB3 gene. This gene encodes a member of the epidermal growth factorreceptor (EGFR) family of receptor tyrosine kinases. This membrane-boundprotein has a neuregulin binding domain but not an active kinase domain.
Source : Human
Host : E. coli
Form : Liquid. Each mg ofprotein contains 1 mg aluminum hydroxide + 10 mM arginine + 10 mM sodiumchloride + 20 mM sodium phosphate buffer + 5 mM potassium. phosphate.
Purity : > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
Molecular Weight : 34 kDa
Biological Activity : Determined by itsability to postpone tumor emerge time of spontaneous breast cancer in FVB/Ntransgenic mice and inhibit the development of tumor and growth of in situ transplantedbreast cancer in FVB/N transgenic mice.
Endotoxin Level : < 0.1 ng/µg ofERBB3
Storage : Store at -20°C to-80°C with a carrier protein (0.1% HSA or BSA) as a stabilizer for long termstorage. Please note that the addition of any carrier protein into this productmay produce unwanted endotoxin. This depends upon the particular application employed.Avoid repeated freeze-thaw cycles.
OfficialSymbol : ERBB3
PDB rendering basedon 1m6b. :

Gene Name : ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homosapiens ]
Synonyms : ERBB3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); HER3;LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3;p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-likeprotein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; EC2.7.10.1; EC 2.7.10
Gene ID : 2065
mRNA Refseq : NM_001005915
Protein Refseq : NP_001005915
MIM : 190151
UniProt ID : P21860
Chromosome Location : 12q13
Pathway : Calcium signalingpathway; Endocytosis; ErbB receptor signaling network; ErbB signalingpathway; ErbB2/ErbB3 signaling events; Heart Development; IL-6 SignalingPathway; a6b1 and a6b4 Integrin signaling
Function : ATP binding; growthfactor binding; nucleotide binding; protein binding; proteinheterodimerization activity; protein tyrosine kinase activator activity; NOTprotein tyrosine kinase activity; receptor activity; receptor signalingprotein tyrosine kinase activity; transmembrane receptor protein tyrosinekinase activity; transmembrane signaling receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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