Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged

• Cat.No.: ERBB3-5193H
• Product Overview: Recombinant HumanTyrosine Kinase ERBB3 (extracellular domain) is a single, non- glycosylated,fusion polypeptide chain containing Thyrodoxin Tag and His tag. The proteinconsists of 190 amino acids (Met1- Cys190). ERBB3 is expressed in E. coli, MW 34kDa.

Specification

• Species: Human
• Source: Human
• Tag: His&Thyrodoxin
• Description: Receptortyrosine-protein kinase ERBB3 is an enzyme that in humans is encoded by theERBB3 gene. This gene encodes a member of the epidermal growth factorreceptor (EGFR) family of receptor tyrosine kinases. This membrane-boundprotein has a neuregulin binding domain but not an active kinase domain.
• Form: Liquid. Each mg ofprotein contains 1 mg aluminum hydroxide + 10 mM arginine + 10 mM sodiumchloride + 20 mM sodium phosphate buffer + 5 mM potassium. phosphate.
• Purity: > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
• Sequence: MRANDALQVLGLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWIREVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDTIDWRDIVRDR DAEIVVKDNG RSCPPCHEVC
• Molecular Weight: 34 kDa
• Biological Activity: Determined by itsability to postpone tumor emerge time of spontaneous breast cancer in FVB/Ntransgenic mice and inhibit the development of tumor and growth of in situ transplantedbreast cancer in FVB/N transgenic mice.
• Endotoxin Level: < 0.1 ng/µg ofERBB3
• Storage: Store at -20°C to-80°C with a carrier protein (0.1% HSA or BSA) as a stabilizer for long termstorage. Please note that the addition of any carrier protein into this productmay produce unwanted endotoxin. This depends upon the particular application employed.Avoid repeated freeze-thaw cycles.
• OfficialSymbol: ERBB3

Gene Information

• Gene Name: ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homosapiens ]
• Synonyms: ERBB3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); HER3;LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3;p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-likeprotein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; EC2.7.10.1; EC 2.7.10
• Gene ID: 2065
• mRNA Refseq: NM_001005915
• Protein Refseq: NP_001005915
• MIM: 190151
• UniProt ID: P21860
• Chromosome Location: 12q13
• Pathway: Calcium signalingpathway; Endocytosis; ErbB receptor signaling network; ErbB signalingpathway; ErbB2/ErbB3 signaling events; Heart Development; IL-6 SignalingPathway; a6b1 and a6b4 Integrin signaling
• Function: ATP binding; growthfactor binding; nucleotide binding; protein binding; proteinheterodimerization activity; protein tyrosine kinase activator activity; NOTprotein tyrosine kinase activity; receptor activity; receptor signalingprotein tyrosine kinase activity; transmembrane receptor protein tyrosinekinase activity; transmembrane signaling receptor activity