Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged ERBB3-5193H

Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged

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Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged

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Cat. No. : ERBB3-5193H
Product Overview : Recombinant HumanTyrosine Kinase ERBB3 (extracellular domain) is a single, non- glycosylated,fusion polypeptide chain containing Thyrodoxin Tag and His tag. The proteinconsists of 190 amino acids (Met1- Cys190). ERBB3 is expressed in E. coli, MW 34kDa.
Description : Receptortyrosine-protein kinase ERBB3 is an enzyme that in humans is encoded by theERBB3 gene. This gene encodes a member of the epidermal growth factorreceptor (EGFR) family of receptor tyrosine kinases. This membrane-boundprotein has a neuregulin binding domain but not an active kinase domain.
Source : Human
Host : E. coli
Form : Liquid. Each mg ofprotein contains 1 mg aluminum hydroxide + 10 mM arginine + 10 mM sodiumchloride + 20 mM sodium phosphate buffer + 5 mM potassium. phosphate.
Purity : > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
Sequence : MRANDALQVLGLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWIREVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDTIDWRDIVRDR DAEIVVKDNG RSCPPCHEVC
Molecular Weight : 34 kDa
Biological Activity : Determined by itsability to postpone tumor emerge time of spontaneous breast cancer in FVB/Ntransgenic mice and inhibit the development of tumor and growth of in situ transplantedbreast cancer in FVB/N transgenic mice.
Endotoxin Level : < 0.1 ng/µg ofERBB3
Storage : Store at -20°C to-80°C with a carrier protein (0.1% HSA or BSA) as a stabilizer for long termstorage. Please note that the addition of any carrier protein into this productmay produce unwanted endotoxin. This depends upon the particular application employed.Avoid repeated freeze-thaw cycles.
OfficialSymbol : ERBB3
PDB rendering basedon 1m6b. :

Gene Name : ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homosapiens ]
Synonyms : ERBB3;v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); HER3;LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3;p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-likeprotein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; EC2.7.10.1; EC 2.7.10
Gene ID : 2065
mRNA Refseq : NM_001005915
Protein Refseq : NP_001005915
MIM : 190151
UniProt ID : P21860
Chromosome Location : 12q13
Pathway : Calcium signalingpathway; Endocytosis; ErbB receptor signaling network; ErbB signalingpathway; ErbB2/ErbB3 signaling events; Heart Development; IL-6 SignalingPathway; a6b1 and a6b4 Integrin signaling
Function : ATP binding; growthfactor binding; nucleotide binding; protein binding; proteinheterodimerization activity; protein tyrosine kinase activator activity; NOTprotein tyrosine kinase activity; receptor activity; receptor signalingprotein tyrosine kinase activity; transmembrane receptor protein tyrosinekinase activity; transmembrane signaling receptor activity

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