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Recombinant Human Charged Multivesicular Body Protein 4A, His-tagged

Cat. No.: CHMP4A-1376H
Product Overview: Recombinant humanCHMP4A protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.
Description: CHMP4A(Chromatin-modifying protein 4a) belongs to the SNF7 family and functions aschromatin-modifying proteins. It probable core component of the endosomalsorting required for transport complex III (ESCRT-III) which is involved inmultivesicular bodies (MVBs) formation and sorting of endosomal cargoproteins into MVBs. Also during HIV-1 infection, the virus uses the ESCRT-IIIcomplex to mediate budding and exocytosis of viral proteins via theassociation of CHMP4 and a protein recruited by HIV-1 p6, which is present inviral Gag assembly and budding. CHMP4A expressed at higher level in heart,kidney, liver and skeletal muscle.
Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 2mM DTT, 50% glycerol, 200mM NaCl, 0.1mMPMSF, 1mM EDTA.
Molecular Weight: 32.0 kDa (285aa),confirmed by MALDI-TOF.
Purity: > 90% by SDS-PAGE
Concentration: 0.25 mg/ml(determined by Bradford assay)
Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MSRRRPEDGL GKAGPCVMRH HPPRSKAEVW RTLRGGGGRG ELAMSGLGRLFGKGKKEKGP TPEEAIQKLK ETEKILIKKQ EFLEQKIQQE LQTAKKYGTK NKRAALQALR RKKRFEQQLAQTDGTLSTLE FQREAIENAT TNAEVLRTME LAAQSMKKAY QDMDIDKVDE LMTDITEQQE VAQQISDAISRPMGFGDDVD EDELLEELEE LEQEELAQEL LNVGDKEEEP SVKLPSVPST HLPAGPAPKV DEDEEALKQLAEWVS
Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: ESCRT-III complex;Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT);Membrane Trafficking
Gene Name: CHMP4A charged multivesicularbody protein 4A [ Homo sapiens ]
Official Symbol: CHMP4A
Synonyms: CHMP4A; charged multivesicular body protein 4A; SNF7;CHMP4; SHAX2; CHMP4B; SNF7-1; VPS32A; HSPC134; VPS32-1; FLJ61658; C14orf123;MGC142093; MGC142095; charged multivesicular body protein 4a;OTTHUMP00000164694; OTTHUMP00000235236; chromatin modifying protein 4A; SNF7homolog associated with Alix-2; Snf7 homologue associated with Alix 2;vacuolar protein sorting-associated protein 32-1
Gene ID: 29082
mRNA Refseq: NM_014169
Protein Refseq: NP_054888
MIM: 610051
UniProt ID: Q9BY43
Chromosome Location: 14q11.2
Function: lipid binding

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