Recombinant Human Charged Multivesicular Body Protein 4A, His-tagged
Cat.No. : | CHMP4A-1376H |
Product Overview : | Recombinant humanCHMP4A protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CHMP4A-1376H |
Description : | CHMP4A(Chromatin-modifying protein 4a) belongs to the SNF7 family and functions aschromatin-modifying proteins. It probable core component of the endosomalsorting required for transport complex III (ESCRT-III) which is involved inmultivesicular bodies (MVBs) formation and sorting of endosomal cargoproteins into MVBs. Also during HIV-1 infection, the virus uses the ESCRT-IIIcomplex to mediate budding and exocytosis of viral proteins via theassociation of CHMP4 and a protein recruited by HIV-1 p6, which is present inviral Gag assembly and budding. CHMP4A expressed at higher level in heart,kidney, liver and skeletal muscle. |
Form : | Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 2mM DTT, 50% glycerol, 200mM NaCl, 0.1mMPMSF, 1mM EDTA. |
Molecular Weight : | 32.0 kDa (285aa),confirmed by MALDI-TOF. |
Purity : | > 90% by SDS-PAGE |
Concentration : | 0.25 mg/ml(determined by Bradford assay) |
Sequences of aminoacids : | MGSSHHHHHHSSGLVPRGSH MSRRRPEDGL GKAGPCVMRH HPPRSKAEVW RTLRGGGGRG ELAMSGLGRLFGKGKKEKGP TPEEAIQKLK ETEKILIKKQ EFLEQKIQQE LQTAKKYGTK NKRAALQALR RKKRFEQQLAQTDGTLSTLE FQREAIENAT TNAEVLRTME LAAQSMKKAY QDMDIDKVDE LMTDITEQQE VAQQISDAISRPMGFGDDVD EDELLEELEE LEQEELAQEL LNVGDKEEEP SVKLPSVPST HLPAGPAPKV DEDEEALKQLAEWVS |
Storage : | Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | ESCRT-III complex;Endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT);Membrane Trafficking |
Gene Name : | CHMP4A charged multivesicularbody protein 4A [ Homo sapiens ] |
Official Symbol : | CHMP4A |
Synonyms : | CHMP4A; charged multivesicular body protein 4A; SNF7;CHMP4; SHAX2; CHMP4B; SNF7-1; VPS32A; HSPC134; VPS32-1; FLJ61658; C14orf123;MGC142093; MGC142095; charged multivesicular body protein 4a;OTTHUMP00000164694; OTTHUMP00000235236; chromatin modifying protein 4A; SNF7homolog associated with Alix-2; Snf7 homologue associated with Alix 2;vacuolar protein sorting-associated protein 32-1 |
Gene ID : | 29082 |
mRNA Refseq : | NM_014169 |
Protein Refseq : | NP_054888 |
MIM : | 610051 |
UniProt ID : | Q9BY43 |
Chromosome Location : | 14q11.2 |
Function : | lipid binding |
Products Types
◆ Recombinant Protein | ||
CHMP4A-3233H | Recombinant Human CHMP4A Protein, MYC/DDK-tagged | +Inquiry |
CHMP4A-1252H | Recombinant Human CHMP4A Protein, GST-Tagged | +Inquiry |
CHMP4A-1251H | Recombinant Human CHMP4A Protein | +Inquiry |
CHMP4A-11186H | Recombinant Human CHMP4A, GST-tagged | +Inquiry |
◆ Lysates | ||
CHMP4A-351HCL | Recombinant Human CHMP4A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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