Recombinant Human Low Density Lipoprotein Receptor Adaptor Protein 1, His-tagged LDLRAP1-1396H

Recombinant Human Low Density Lipoprotein Receptor Adaptor Protein 1, His-tagged

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Recombinant Human Low Density Lipoprotein Receptor Adaptor Protein 1, His-tagged

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Cat. No. : LDLRAP1-1396H
Product Overview : Recombinant human LDLRAP1 protein, fused to His-tag atN-terminus, was expressed in E. coli andpurified by using conventional chromatography techniques.
Description : LDLRAP1(Low density lipoprotein receptor adapter protein 1) is a cytosolic proteinwhich contains a phosphotyrosine binding (PTD) domain. LDLRAP1 is a cytosolic adaptor that couples LDLR to endocyticmachinery. Defects in LDLRAP1are the cause of autosomal recessive hypercholesterolemia (ARH). ARH is adisorder caused by defective internalization of LDL receptors (LDLR) in theliver.
Form : Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 2mM DTT, 10% glycerol, 200mM NaCl.
Molecular Weight : 36.1 kDa (328aa), confirmed by MALDI-TOF.
Purity : > 90%by SDS-PAGE
Concentration : 0.5mg/ml(determined by Bradford assay)
Sequences of aminoacids : MGSSHHHHHHSSGLVPRGSH MDALKSAGRA LIRSPSLAKQ SWGGGGRHRK LPENWTDTRE TLLEGMLFSLKYLGMTLVEQ PKGEELSAAA IKRIVATAKA SGKKLQKVTL KVSPRGIILT DNLTNQLIEN VSIYRISYCTADKMHDKVFA YIAQSQHNQS LECHAFLCTK RKMAQAVTLT VAQAFKVAFE FWQVSKEEKE KRDKASQEGGDVLGARQDCT PPLKSLVATG NLLDLEETAK APLSTVSANT TNMDEVPRPQ ALSGSSVVWE LDDGLDEAFSRLAQSRTNPQ VLDTGLTAQD MHYAQCLSPV DWDKPDSSGT EQDDLFSF
Storage : Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
OfficialSymbol : LDLRAP1
nullValue_other :
PathwaysChylomicron-mediatedlipid transport; Endocytosis; LDL-mediated lipid transport; Lipid digestion,mobilization, and transport ;Lipoprotein metabolism; Metabolism of lipids andlipoproteins
Gene Name : LDLRAP1 low density lipoproteinreceptor adaptor protein 1 [ Homo sapiens ]
Synonyms : LDLRAP1; low densitylipoprotein receptor adaptor protein 1; ARH; ARH1; ARH2;FHCB1; FHCB2; MGC34705; DKFZp586D0624; OTTHUMP00000008526; LDL receptoradaptor protein; autosomal recessive hypercholesterolemia protein; Lowdensity lipoprotein receptor adaptor protein 1; Autosomal recessivehypercholesterolemia protein
Gene ID : 26119
mRNA Refseq : NM_015627
Protein Refseq : NP_056442
MIM : 605747
UniProt ID : Q5SW96
Chromosome Location : 1p36-p35

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