"PTK6" Related Products


Recombinant Human PTK6 Protein Tyrosine Kinase 6, His-tagged

Cat. No. : PTK6-1905H
Product Overview : Recombinant humanfull length PTK6 with His Tag.
Description : PTK6, also known as Breasttumor Kinase (BRK), is a Src-like nonreceptor tyrosine kinase, which belongsto Tyr protein kinase family. It is overexpressed in the majority of breastcancer and several other cancer types, while being detected at appreciablelevels in only a limited range of adult tissues that does not include themammary gland. PTK6 contains SH3, SH2, and Kinase domains, with a linkerregion (Linker) between the SH2 and Kinase domains, and the structural basisof the SH3-Linker interaction that results in auto-inhibition of PTK6.
Source : insect cells
Species : Human
Form : Liquid in 50 mMTris, pH 7.5 + 200 mM NaCl + 1 mM EDTA + 0.05% Triton X-100 + 5 mM DTT + 50%glycerol.
Molecular Weight : 55.4 kDa
Purity : ≥ 95%
Biological Activity : 166 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 2 ug/ml.
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : PTK6
NMRstructure of the SH2 domain of PTK6. :

Gene Name : PTK6 PTK6 protein tyrosinekinase 6 [ Homo sapiens ]
Synonyms : PTK6; PTK6 protein tyrosinekinase 6; BRK; FLJ42088; breast tumor kinase; protein-tyrosine kinase BRK; EC2.7.10.2; Tyrosine-protein kinase 6; OTTHUMP00000031656; Tyrosine-proteinkinase BRK
Gene ID : 5753
mRNA Refseq : NM_005975
Protein Refseq : NP_005966
MIM : 602004
UniProt ID : Q13882
Chromosome Location : 20q13.3
Pathway : EGFR1 Signaling Pathway; Focal Adhesion
Function : ATP binding; non-membranespanning protein tyrosine kinase activity; nucleotide binding; proteinbinding; protein serine/threonine kinase activity; transferase activity

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