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Recombinant Human Retinoid X Receptor, Alpha, His-tagged

Cat. No. : RXRA-5479H
Product Overview : Recombinant HumanHis-tagged Retinoid X Receptor-alpha containing amino acids 200-462 (LigandBinding Domain) under the control of a T7 promoter.
Description : RetinoidX receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily2, group B, member 1) is a nuclear receptor that in humans is encoded by theRXRA gene.
Source : E. coli
Species : Human
Form : Liquid in 20 mMTris-HCl, pH 8.0 + 100 mM KCl + 0.2 mM EDTA + 1 mM DTT + 20% glycerol.
Purity : > 95% asdetermined by SDS-PAGE analysis.
Applications : In vitrotranscription assays, DNA, and protein-protein interactions assays.
Storage : Stable for 1 year inworking aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : RXRA
Pathways : Adipocytokinesignaling pathway; Adipogenesis; Bile secretion; Developmental Biology;Energy Metabolism; Gene Expression; Generic Transcription P; Hepatitis C;IL-3 Signaling Pathway; Metabolism of lipids and lipoproteins; Non-small celllung cancer; Nuclear Receptor transcription pathway; Nuclear Receptors; PPARsignaling pathway; Pathways in cancer
PDB rendering basedon 1by4. :

Gene Name : RXRA retinoid X receptor, alpha[ Homo sapiens ]
Synonyms : RXRA; retinoidX receptor, alpha; NR2B1; retinoic acid receptor RXR-alpha;OTTHUMP00000022510; retinoid X nuclear receptor alpha; nuclear receptorsubfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; Nuclear receptor subfamily 2 group B member 1; Retinoid Xreceptor alpha
Gene ID : 6256
mRNA Refseq : NM_002957
Protein Refseq : NP_002948
MIM : 180245
UniProt ID : P19793
Chromosome Location : 9q34
Function : DNA binding;double-stranded DNA binding; enzyme binding; ligand-regulated transcriptionfactor activity; metal ion binding; protein binding; proteinheterodimerization activity; receptor activity; retinoic acid receptoractivity; retinoic acid-responsive element binding; retinoid-X receptoractivity; sequence-specific DNA binding; sequence-specific DNA bindingtranscription factor activity; steroid binding; steroid hormone receptoractivity; transcription coactivator activity

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