Recombinant Human Vascular Endothelial Growth Factor A

• Cat.No.: VEGFA-5529H
• Product Overview: Recombinant human VEGF145induced the proliferation of vascular endothelial cells and promotedangiogenesis in vivo.

Specification

• Cat. No.: VEGFA-5529H
• Description: This gene is a memberof the platelet-derived growth factor (PDGF)/vascular endothelial growthfactor (VEGF) family and encodes a protein that is often found as a disulfidelinked homodimer. This protein is a glycosylated mitogen that specificallyacts on endothelial cells and has various effects.
• Source: Produced in Sf9insect cells
• Species: Human
• Form: Lyophilized
• Purity: Purified by affinitychromatography using Heparin-Sepharose as matrix. 95%, by SDSPAGE andvisualized by silver staingel.
• Molecular Mass: 41 kDa
• Endotoxin Level: < 0.1 ng per μgof VEGF
• Biological Activity: The ED50for stimulation of 3H-thymidine incorporation and cellproliferation by human umbilical vein endothelial cells for VEGF145has been determined to be in the range of 10 ng/ml.
• Specific Activity: 2.5 x 105units/mg
• Notes: Units per vial: 0.5x 103; Range: 5-40 ng/ml; Coomassiestain 95%, by SDS-PAGE and visualized by silver stain.
• OfficialSymbol: VEGFA
• Pathways: Bladder cancer;Cytokine-cytokine receptor interaction; Endochondral Ossification; Focaladhesion; Glypican 1 network; HIF-1-alpha transcription factor network;HIF-2-alpha transcription factor network; Heart Development; Hemostasis;Hypertrophy Model; Id Signaling Pathway; Integrins in angiogenesis;Neurophilin interactions with VEGF and VEGFR; Pancreatic cancer; Pathways incancer

Gene Information

• Gene Name: VEGFA vascular endothelialgrowth factor A [ Homo sapiens ]
• Synonyms: VEGFA;vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascularendothelial growth factor A; OTTHUMP00000016487; OTTHUMP00000016488;OTTHUMP00000165985; OTTHUMP00000165986; OTTHUMP00000165987; OTTHUMP00000224107;OTTHUMP00000224108; OTTHUMP00000224109; OTTHUMP00000224153;OTTHUMP00000224154; OTTHUMP00000224423; OTTHUMP00000224424;OTTHUMP00000224425; OTTHUMP00000224426; OTTHUMP00000224427;OTTHUMP00000224428; OTTHUMP00000224429; OTTHUMP00000224430; vascularpermeability factor; Vascular endothelial growth factor A; Vascular permeability factor
• Gene ID: 7422
• mRNA Refseq: NM_001025366
• Protein Refseq: NP_001020537
• MIM: 192240
• UniProt ID: P15692
• Chromosome Location: 6p12
• Function: cell surfacebinding; chemoattractant activity; cytokine activity; extracellular matrixbinding; fibronectin binding; growth factor activity; heparin binding;platelet-derived growth factor receptor binding; protein binding; proteinheterodimerization activity; vascular endothelial growth factor receptor 1binding; vascular endothelial growth factor receptor 2 binding; vascularendothelial growth factor receptor binding