Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, His-tagged


Home / Products / Recombinant Proteins / Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, His-tagged

Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, His-tagged

SERPINE1 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat. No. : SERPINE1-5506H
Product Overview : Recombinant human SERPINE1containing four mutations that stabilize the activity of PAI-1. TheN-terminus has been modified with a 6xHis tag, which allows for theimmobilization of functionally active PAI-1 onto surfaces such as metal chelatemicrotiter plates or Ni+2 resins.
Description : SERPINE1 also knownas endothelial plasminogen activator inhibitor or serpin E1 is a protein thatin humans is encoded by the SERPINE1 gene. SERPINE1 is a serine proteaseinhibitor (serpin) that functions as the principal inhibitor of tissueplasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (SERPINE1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. Inaddition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1,however, is the main inhibitor of the plasminogen activators.
Source : E. coli
Species : Human
Molecule Weight : 43.0 kDa
Form : Frozen liquid in0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
Concentration : 2.5 mg/ml
Storage : Storein working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : SERPINE1
Pathways : Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade;Complement and Coagulation Cascades; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-2-alpha transcription factor network;Platelet activation; Platelet degranulation; Regulation of nuclear SMAD2/3signaling; Response to elevated platelet cytosolic Ca2+; Selenium Pathway; Senescenceand Autophagy; TGF Beta Signaling Pathway; p53 signaling pathway
Gene Name : SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ]
Synonyms : SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpinE1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine(or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activatorinhibitor type 1), member 1
Gene ID : 5054
mRNA Refseq : NM_000602
Protein Refseq : NP_000593
MIM : 173360
UniProt ID : P05121
Chromosome Location : 7q21.3-q22
Function : peptidase inhibitoractivity; protease binding; protein binding; contributes to receptor binding;serine-type endopeptidase inhibitor activity

Online Inquiry

  • Note: There will be extra charge for optional service!
  • Verification Code Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy