Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, His-tagged

• Cat.No.: SERPINE1-5506H
• Product Overview: Recombinant human SERPINE1containing four mutations that stabilize the activity of PAI-1. TheN-terminus has been modified with a 6xHis tag, which allows for theimmobilization of functionally active PAI-1 onto surfaces such as metal chelatemicrotiter plates or Ni+2 resins.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: SERPINE1 also knownas endothelial plasminogen activator inhibitor or serpin E1 is a protein thatin humans is encoded by the SERPINE1 gene. SERPINE1 is a serine proteaseinhibitor (serpin) that functions as the principal inhibitor of tissueplasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein (SERPINE1). Theother PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by theplacenta and only present in significant amounts during pregnancy. Inaddition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1,however, is the main inhibitor of the plasminogen activators.
• Molecule Weight: 43.0 kDa
• Form: Frozen liquid in0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
• Concentration: 2.5 mg/ml
• Storage: Storein working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: SERPINE1
• Pathways: Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade;Complement and Coagulation Cascades; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-2-alpha transcription factor network;Platelet activation; Platelet degranulation; Regulation of nuclear SMAD2/3signaling; Response to elevated platelet cytosolic Ca2+; Selenium Pathway; Senescenceand Autophagy; TGF Beta Signaling Pathway; p53 signaling pathway

Gene Information

• Gene Name: SERPINE1 serpin peptidaseinhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1[ Homo sapiens ]
• Synonyms: SERPINE1; serpinpeptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpinE1; OTTHUMP00000211478; endothelial plasminogen activator inhibitor; serine(or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activatorinhibitor type 1), member 1
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• UniProt ID: P05121
• Chromosome Location: 7q21.3-q22
• Function: peptidase inhibitoractivity; protease binding; protein binding; contributes to receptor binding;serine-type endopeptidase inhibitor activity