Native Human Thyroid Stimulating Hormone, Beta

• Cat.No.: TSHB-704H
• Product Overview: Native human TSHB ispurified Human pituitary glands.

Specification

• Cat. No.: TSHB-704H
• Description: The four humanglycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), folliclestimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimersconsisting of alpha and beta subunits that are associated noncovalently. Thealpha subunits of these hormones are identical, however, their beta chainsare unique and confer biological specificity. Thyroid stimulating hormonefunctions in the control of thyroid structure and metabolism. The proteinencoded by this gene is the beta subunit of thyroid stimulating hormone.Mutations in this gene result in congenital hypothyroidism.
• Source: Human pituitaryglands
• Form: Lyophilized from0.05 M ammonium bicarbonate.
• Concentration: 1.0 mg/mL
• Purity: > 98% asdetermined by SDS-PAGE analysis
• Reconstitution: Centrifuge vialprior to opening. Add 50 mM Tris, pH 7.5 to the vial to fully solubilize theprotein to a concentration of 1-2 mg/ml.
• Storage: Store at -20°C. Avoidrepeated freeze-thaw cycles.
• OfficialSymbol: TSHB

Gene Information

• Gene Name: TSHB thyroid stimulatinghormone, beta [ Homo sapiens ]
• Synonyms: TSHB; thyroidstimulating hormone, beta; TSH-BETA; TSH-B; CHNG4; TSH-beta; Thyrotropinalfa; thyrotropin subunit beta; thyrotropin beta chain; thyrotropin betasubunit; thyroid-stimulating hormone subunit beta
• Gene ID: 7252
• mRNA Refseq: NM_000549
• Protein Refseq: NP_000540
• MIM: 188540
• UniProt ID: P01222
• Chromosome Location: 1p13
• Pathway: Amine-derivedhormones; Autoimmune thyroid disease; Class A/1 (Rhodopsin-like receptors); Galpha (s) signalling events; GPCR downstream signaling; GPCR ligand binding;Glycoprotein hormones; Hormone ligand-binding receptors; Metabolism;Metabolism of amino acids and derivatives; Neuroactive ligand-receptorinteraction; Peptide hormone biosynthesis; Signal Transduction; Signaling byGPCR; Thyroxine biosynthesis
• Function: hormone activity