"CSF2" Related Products

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Recombinant Monkey Colony Stimulating Factor 2 (granulocyte-macrophage)

Cat. No.: CSF2-382M
Product Overview: Recombinant MonkeyCSF2 is a single non-glycosylated polypeptide chain containing 127 aminoacids.
Description: CSF2 was initiallycharacterized as a growth factor that can support the in vitro colonyformation of granulocyte-macrophage progenitors. It is produced by a numberof different cell types (including activated T cells, B cells, macrophages,mast cells, endothelial cells and fibroblasts) in response to cytokine orimmune and inflammatory stimuli. Besides granulocyte-macrophage progenitors,CSF2 is also a growth factor for erythroid, megakaryocyte and eosinophilprogenitors. On mature hematopoietic cells, CSF2 is a survival factor for andactivates the effector functions of granulocytes, monocytes, macrophages, andeosinophils.
Source: E. coli
Species: Monkey
Form: Lyophilized from a0.2 µm filtered concentrated solution in PBS, pH 7.4.
Molecular Weight: 14.4 kDa
Sequence: APARSPSPGTQPWEHVNAIQ EARRLLNLSR DTAAEMNKTV EVVSEMFDLQEPSCLQTRLE LYKQGLQGSL TKLKGPLTMMASHYKQHCPP TPETSCATQIITFQSFKENL KDFLLVIPFD CWEPVQE
Purity: > 98% by SDS-PAGEand HPLC analyses
Biological Activity: Fully biologicallyactive when compared to standard. The ED50 as calculated by the dose-dependant stimulation of the proliferation of human TF-1 cells is less than0.1 ng/ml, corresponding to a Specific Activity of 1.0×107 IU/mg.
Endotoxin Level: < 0.1 ng/µg ofprotein
Reconstitution: Centrifuge vialprior to opening. Reconstitute in sterile distilled water or aqueous buffercontaining 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutionsshould be apportioned into working aliquots and stored at ≤-20°C. Further dilutionsshould be made in appropriate buffered solutions.
Storage: The lyophilizedprotein is stable at 2-4°C, but should be kept desiccated at -20°C for longterm storage. After reconstitution, the protein is stable for 1 week at2-4°C. For long term storage, aliquot and freeze at -80°C. Avoid repeatedfreeze-thaw cycles.
OfficialSymbol: CSF2
Gene Name: CSF2 colony stimulating factor 2(granulocyte-macrophage) [ Macaca mulatta ]
Synonyms: CSF2; colony stimulating factor 2 (granulocyte-macrophage);GM-CSF
Gene ID: 574371
mRNA Refseq: NM_001032949
Protein Refseq: NP_001028121
Pathway: Amoebiasis; CytokineSignaling in Immune system; Cytokine-cytokine receptor interaction; Fcepsilon RI signaling pathway; HTLV-I infection; Hematopoietic cell lineage;Interleukin-3, 5 and GM-CSF signaling; Jak-STAT signaling pathway; Naturalkiller cell mediated cytotoxicity; Rheumatoid arthritis; Salmonellainfection; T cell receptor signaling pathway

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