Recombinant Human V-Erb-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (avian), GST-tagged

• Cat.No.: ERBB4-1218H
• Product Overview: Recombinant humanERBB4 catalytic domain (aa 708-993) with N-terminal GST tag. No special measureswere taken to activate this kinase.

Specification

• Cat. No.: ERBB4-1218H
• Description: Receptortyrosine-protein kinase ERBB4 is an enzyme that in humans is encoded by theERBB4 gene. Alternatively spliced variants thatencode different protein isoforms have been described; however, not allvariants have been fully characterized.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• Molecular Weight: 61.6 kDa
• Concentration: 0.34 mg/ml
• Specific Activity: 550 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 2μg/ml.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: ERBB4

Gene Information

• Gene Name: ERBB4 v-erb-a erythroblastic leukemiaviral oncogene homolog 4 (avian) [ Homo sapiens ]
• Synonyms: ERBB4; v-erb-aerythroblastic leukemia viral oncogene homolog 4 (avian); HER4;MGC138404; p180erbB4; receptor tyrosine-protein kinase erbB-4; OTTHUMP00000163968;OTTHUMP00000206623; OTTHUMP00000209432; proto-oncogene-like protein c-ErbB-4;tyrosine kinase-type cell surface receptor HER4; avian erythroblasticleukemia viral (v-erb-b2) oncogene homolog 4
• Gene ID: 2066
• mRNA Refseq: NM_005235
• Protein Refseq: NP_005226
• MIM: 600543
• UniProt ID: Q15303
• Chromosome Location: 2q33.3-q34
• Pathway: Calcium signalingpathway; Endocytosis; ErbB signaling pathway
• Function: ATP binding;nucleotide binding; protein binding; receptor activity; receptor signalingprotein tyrosine kinase activity; transmembrane receptor protein tyrosinekinase activity