Native Human Beta-2-Microglobulin

Cat.No.: B2M-5366H
Product Overview: Native human B2M was expressed in Human plasma.
Description: HumanB2M produced in Human urine from patients with tubular proteinuria has aMW=12 kDa and p1 of 5.6. Human Beta 2 microglobulin levels can rise eitherbecause its rate of synthesis has increased (e.g. in AIDS, malignantmonoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) orbecause of impaired renal filtration (e.g. due to renal insufficiency, graftrejection or nephrotoxicity induced by post-transplantation immunosuppressivetherapy).
Source: Human urine frompatients with tubular proteinuria
Species: Human
Form: Sterile filtered andthen lyophilized from 0.02M NHQHCO3.
Purity: ≥98.0%
Storage: Human B2M althoughstable at room temperature for 3 weeks, should be stored between 2-4°C.
Reconstitution: Centrifuge vialprior to opening. Reconstitute the lyophilized protein in phosphate buffer pH 7.0 containing 0.15 M NaCI.
Gene Name: B2M beta-2-microglobulin [ Homo sapiens ]
Official Symbol: B2M
Synonyms: B2M; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules;
Gene ID: 567
mRNA Refseq: NM_004048
Protein Refseq: NP_004039
MIM: 109700
UniProt ID: P61769
Chromosome Location: 15q21-q22.2
Pathway: Adaptive Immune System, organism-specific biosystem; Amyloids, organism-specific biosystem; Antigen Presentation: Folding, assembly and peptide loading of class I MHC, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing and
Function: protein binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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