"IGF2" Related Products


Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A)

Cat. No.: IGF2-620H
Product Overview: Recombinant human IGF2 is a single, non-glycosylated polypeptidechain containing 67 amino acids and has a MW 7.5 kDa.
Description: This gene encodes a member of the insulin family of polypeptidegrowth factors, which are involved in development and growth. It is animprinted gene, expressed only from the paternal allele, and epigeneticchanges at this locus are associated with Wilms tumour, Beckwith-Wiedemannsyndrome, rhabdomyosarcoma, and Silver-Russell syndrome.
Source: E. coli
Species: Human
Form: Sterile filtered,then lyophilized with no additives.
Purity: > 97.0%as determined by RP-HPLC and SDS-PAGE under reducing and non-reducing conditions.
Endotoxin Level: < 0.1 ng/μg ofrecombinant human IGF2.
Biological Activity: TheED50 as determined by a cell proliferation assay using FDC-P1cells is < 2.0 ng/ml.
Specific Activity: >5 x 105 units/mg
Reconstitution: Centrifuge vial prior to opening.Reconstitute in sterile water at a concentration of 0.1 mg/ml. After completesolubilization of the protein, it can be further diluted to other aqueoussolutions.
Storage: Store thelyophilized product at -20°C. After reconstitution, aliquot and freeze at -20°C.For long term storage, it recommended to add a carrier protein (0.1% HSA orBSA). Please note that the addition of any carrier protein into this productmay produce unwanted endotoxin. This depends upon the particular applicationemployed. Avoid repeated freeze-thaw cycles.
OfficialSymbol: IGF2
Gene Name: IGF2insulin-like growth factor 2 (somatomedin A) [ Homo sapiens ]
Synonyms: IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II; somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013;OTTHUMP00000011015; OTTHUMP00000011016; OTTHUMP00000011017; OTTHUMP00000011018;OTTHUMP00000011157; OTTHUMP00000011158; OTTHUMP000000220667; insulin-likegrowth factor type 2; Insulin-like growth factor II Ala-25 Del; Preptin;PP1446; chromosome 11 open reading frame 43
Gene ID: 3481
mRNA Refseq: NM_000612
Protein Refseq: NP_000603
MIM: 147470
UniProt ID: P01344
Chromosome Location: 11p15.5
Pathway: Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Singling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)
Function: growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity

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