"Il13" Related Products

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Recombinant Mouse Interleukin 13

Cat. No.: Il13-629M
Product Overview: Recombinant Mouse Il13 is expressed in E. coli.
Description: Il13 isan immunoregulatory cytokine produced primarily by activated Th2 cells, and alsoby mast cells and NK cells. Targeted deletion of Il13 in mice resulted inimpaired Th2 cell development and indicated an important role for Il13 in theexpulsion of gastrointestinal parasites. Il13 exerts anti-inflammatoryeffects on monocytes and macrophages and it inhibits the expression ofinflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. Il13 hasalso been shown to enhance B cell proliferation and to induce isotypeswitching resulting in increased production of IgE. Blocking of Il13 activityinhibits the pathophysiology of asthma. Human and murine Il13 iscross-species reactive.
Source: E. coli
Species: Mouse
Form: Lyophilized from a0.2um filtered concentrated (1mg/ml) solution in PBS, pH 7.4.
Molecular Weight: Approximately 12.3kDa
Purity: > 95%by SDS-PAGE and HPLC analyses.
Endotoxin Level: Less than 1EU/ug ofrMuIL-13 variant as determined by LAL method.
Biological Activity: Fullybiologically active when compared to standard. The ED50 asdetermined by the dose-dependent proliferation of TF-1 cells was < 4.0ng/ml, corresponding to a specific activity of > 2.5×105units/mg.
AminoAcid Sequence: MPVPRSVSLPLTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTTVSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Reconstitution: Werecommend that this vial be briefly centrifuged prior to opening to bring thecontents to the bottom. Reconstitute in sterile distilled water or aqueousbuffer to a concentration of 0.1-1.0 mg/ml. Stock solutions should beapportioned into working aliquots and stored at ≤20°C. Furtherdilutions should be made in appropriate buffered solutions.
Storage: Thislyophilized preparation is stable for several weeks at 2-8°C, but should bekept at -20°C for long term storage, preferably desiccated. Uponreconstitution, the preparation is stable for up to one week at 2-8°C. Formaximal stability, apportion the reconstituted preparation into workingaliquots and store at -20°C to -80°C. Avoid repeated freeze/thaw cycles.
OfficialSymbol: Il13
Gene Name: Il13interleukin 13 [ Mus musculus ]
Synonyms: Il13; interleukin13; Il-13;interleukin-13;OTTMUSP00000005816; T-cell activation protein P600; IL-13
Gene ID: 16163
mRNA Refseq: NM_008355
Protein Refseq: NP_032381
UniProt ID: P20109
Chromosome Location: 11
Pathway: Asthma; Cytokine-cytokinereceptor interaction; Cytokines and Inflammatory Response (BioCarta); Fcepsilon RI signaling pathway; ak-STAT signaling pathway; Measles
Function: cytokineactivity; cytokine receptor binding; interleukin-13 receptor binding

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