"PRKCA" Related Products

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Recombinant Human Protein Kinase C, Alpha, His-tagged

Cat. No.: PRKCA-1301H
Product Overview: Therecombinant human PRKCA was expressed in E. coli and purified by Ni-agarose chromatography.It is suitable for labeling PKC substrates.
Description: PRKCA isa serine/threonine kinase and a member of the conventional (classical) PKCs(cPKCs), which have four conserved (C1 to C4) regions. This ubiquitouslyexpressed PKC isotype is activated in response to many different kinds ofstimuli and translocates from cytosol to the specialized cellularcompartments (nucleus, focal adhesion, caveolae, etc.) where it is presumedto work. Therefore, PRKCA has been implicated in a variety of cellularfunctions including proliferation, apoptosis, differentiation, motility, andinflammation.
Source: E. coli
Species: Human
Form: Liquid ina 20 mM NaH2PO4 buffer, pH 7.8, + 500 mM NaCl + 1 mM Na-orthovanadate + 5 mMNaF + 40 mM β-glycerophosphate + 5% glycerol.
Molecular Weight: 81.9 kDa
Purity: > 95% by SDS-PAGE
Specific Activity: >200,000 U/mg (1 Unit is defined as 1 picomole phosphate transferred to PKCpeptide QKRPSQRSKYL per min at 30°C).
Endotoxin Level: < 0.1ng/μg of protein.
Storage: For longterm storage, aliquot and freeze at -80°C. Stable for 1 year. Avoid repeated freeze-thawcycles.
OfficialSymbol: PRKCA
nullValue_other:
Functionnucleotide binding; proteinbinding; protein kinase activity; protein serine/threonine kinase activity; zincion binding; metal ion binding; histone kinase activity (H3-T6 specific); enzymebinding; ATP binding
Gene Name: PRKCA protein kinase C, alpha [ Homosapiens ]
Synonyms: PRKCA; proteinkinase C, alpha; AAG6; PKCA; PRKACA; MGC129900; MGC129901; PKC-alpha; proteinkinase C, alpha type; PKC-A; aging-associated gene 6; EC2.7.11.13
Gene ID: 5578
mRNA Refseq: NM_002737
Protein Refseq: NP_002728
MIM: 176960
UniProt ID: P17252
Chromosome Location: 17q22-q24
Pathway: ATF-2 transcription factornetwork; African trypanosomiasis; Aldosterone-regulated sodium reabsorption; Alpha6-Beta4Integrin Signaling Pathway; Amoebiasis; Ca-dependent events; CaM pathway; CalciumRegulation in the Cardiac Cell; Calcium signaling pathway; Calmodulin inducedevents; Canonical NF-kappaB pathway; Cholinergic synapse; DAG and IP3signaling; Disinhibition of SNARE formation; Dopaminergic synapse

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