"Plau" Related Products

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Recombinant Mouse Plasminogen Activator, Urokinase

Cat. No.: Plau-1294M
Product Overview: Recombinant MouseLow Molecular Weight Urokinase Active.
Description: Plau encodes aserine protease involved in degradation of the extracellular matrix andpossibly tumor cell migration and proliferation. A specific polymorphism inthis gene may be associated with late-onset Alzheimer disease and also withdecreased affinity for fibrin-binding. Plau encoded by this gene convertsplasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.This two-chain derivative is also called Plau. Plau can be further processedinto LMW- Plau (low molecular weight Plau) by cleavage of chain A into ashort chain A (A1) and an amino-terminal fragment. LMW- Plau isproteolytically active but does not bind to the Plau receptor.
Source: Insect cells
Species: Mouse
Form: Liquid in 0.05 Msodium acetate + 0.1 M NaCl + 1 mM EDTA, pH 5.0
Molecular Weight: 31.0 kDa
Concentration: 2.0 mg/ml
Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: Plau
Gene Name: Plau plasminogen activator,urokinase [ Mus musculus ]
Synonyms: Plau; plasminogenactivator, urokinase; PA; u-PA; urokinase-type plasminogen activator;U-plasminogen activator; EC 3.4.21.73
Gene ID: 18792
mRNA Refseq: NM_008873
Protein Refseq: NP_032899
UniProt ID: P06869
Chromosome Location: 14 A3; 14 2.5 cM
Pathway: Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Wnt Signaling Pathway; Wnt SignalingPathway and Pluripotency
Function: catalytic activity;hydrolase activity; kinase activity; peptidase activity; serine-typeendopeptidase activity; serine-type peptidase activity

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