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Recombinant Mouse Plasminogen Activator, Urokinase

Cat.No. : Plau-1294M
Product Overview : Recombinant MouseLow Molecular Weight Urokinase Active.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : Plau-1294M
Description : Plau encodes aserine protease involved in degradation of the extracellular matrix andpossibly tumor cell migration and proliferation. A specific polymorphism inthis gene may be associated with late-onset Alzheimer disease and also withdecreased affinity for fibrin-binding. Plau encoded by this gene convertsplasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.This two-chain derivative is also called Plau. Plau can be further processedinto LMW- Plau (low molecular weight Plau) by cleavage of chain A into ashort chain A (A1) and an amino-terminal fragment. LMW- Plau isproteolytically active but does not bind to the Plau receptor.
Source : Insect cells
Species : Mouse
Form : Liquid in 0.05 Msodium acetate + 0.1 M NaCl + 1 mM EDTA, pH 5.0
Molecular Weight : 31.0 kDa
Concentration : 2.0 mg/ml
Storage : Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : Plau
Gene Name : Plau plasminogen activator,urokinase [ Mus musculus ]
Synonyms : Plau; plasminogenactivator, urokinase; PA; u-PA; urokinase-type plasminogen activator;U-plasminogen activator; EC 3.4.21.73
Gene ID : 18792
mRNA Refseq : NM_008873
Protein Refseq : NP_032899
UniProt ID : P06869
Chromosome Location : 14 A3; 14 2.5 cM
Pathway : Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Wnt Signaling Pathway; Wnt SignalingPathway and Pluripotency
Function : catalytic activity;hydrolase activity; kinase activity; peptidase activity; serine-typeendopeptidase activity; serine-type peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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