"PDGFRB" Related Products

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Recombinant Human Platelet-Derived Growth Factor Receptor, Beta Polypeptide, His-tagged

Cat. No.: PDGFRB-1890H
Product Overview: Recombinant humanPDGFRB catalytic domain (amino acids 558-1106), His-tagged was expressed ininsect cells. Its molecular weight is 66300 Dalton.
Description: PDGFRB is a receptortyrosine kinase and has been implicated in atherogenesis and in celltransformation by the SIS oncogene. No special measures were taken toactivate this kinase. PDGFRB encodes a cell surface tyrosine kinase receptorfor members of the platelet-derived growth factor family. These growthfactors are mitogens for cells of mesenchymal origin. The identity of thegrowth factor bound to a receptor monomer determines whether the functionalreceptor is a homodimer or a heterodimer, composed of both platelet-derivedgrowth factor receptor alpha and beta polypeptides. PDGFRB is flanked onchromosome 5 by the genes for granulocyte-macrophage colony-stimulatingfactor and macrophage-colony stimulating factor receptor; all three genes maybe implicated in the 5-q syndrome.
Source: Insect cells
Species: Human
Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
Molecular Weight: 66.3 kDa
Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: PDGFRB
Gene Name: PDGFRB platelet-derived growth factorreceptor, beta polypeptide [ Homo sapiens ]
Synonyms: PDGFRB;platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR;CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta;CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140bantigen; soluble PDGFRb variant; Beta-type platelet-derived growth factorreceptor
Gene ID: 5159
mRNA Refseq: NM_002609
Protein Refseq: NP_002600
MIM: 173410
UniProt ID: P09619
Chromosome Location: 5q33.1
Pathway: Calcium signalingpathway; Cytokine-cytokine receptor interaction; Downstream signaltransduction; Focal adhesion; Gap junction; Glioma; HTLV-I infection; MAPKsignaling pathway; Melanoma; Pathways in cancer; PDGFR-alpha signalingpathway; Regulation of actin cytoskeleton; Signaling by PDGF; S1P1 pathway;S1P3 pathway
Function: ATP binding; growthfactor binding; nucleotide binding; platelet activating factor receptoractivity; platelet-derivedgrowth factor alpha-receptor activity; platelet-derived growth factorbinding; platelet-derived growth factor receptor binding; proteinhomodimerization activity; platelet-derived growth factor-activated receptoractivity; protein binding; protein tyrosine kinase activity; receptoractivity; receptor bingding; signal transducer activity; vascular endothelialgrowth factor-activated receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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