"PDPK1" Related Products

Recombinant Human 3-Phosphoinositide Dependent Protein Kinase-1, His-tagged

Cat. No.: PDPK1-1891H
Product Overview: Recombinant humanPDPK1 was expressed in insect cells. Its molecular weight is 66900 Dalton.
Description: PDPK1 is aserine/threonine protein kinase localized to the plasma membrane. It plays avital role in insulin-induced glycogen synthesis, PKC activation, andactivation of the AGC subfamily of protein kinases. No special measures weretaken to activate this kinase. PDPK1 is a master kinase, which is crucial forthe activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK.An important role for PDPK1 is in the signalling pathways activated byseveral growth factors and hormones including insulin signalling.
Source: Insect cells
Species: Human
Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
Molecular Weight: 66.9 kDa
Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol: PDPK1
Gene Name: PDPK1 3-phosphoinositide dependent proteinkinase-1 [ Homo sapiens ]
Synonyms: PDPK1; 3-phosphoinositidedependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1;PDK1; PRO0461; MGC20087; MGC35290; PkB kinase; hPDK1; EC 2.7.11.1
Gene ID: 5170
mRNA Refseq: NM_002613
Protein Refseq: NP_002604
MIM: 605213
UniProt ID: O15530
Chromosome Location: 16p13.3
Pathway: Activation of NMDA receptorupon glutamate binding and postsynaptic events; Activation of PKB; AdaptiveImmune System; Aldosterone-regulated sodium reabsorption; B Cell ReceptorSignaling Pathway; BCR signaling pathway; CD28 co-stimulation; CD28 dependentPI3K/Akt signaling; Class I PI3K signaling events; Costimulation by the CD28family; Focal adhesion; Hemostasis; IGF1 pathway; IRS-mediated Signaling;Insulin Pathway
Function: 3-phosphoinositide-dependentprotein kinase activity; ATP binding; kinase activity; nucleotide binding;protein binding; protein serine/threonine kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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